Riesgo cardiovascular en personas con colangitis biliar primaria, revisión de la literatura
Resumen
La colangitis biliar primaria (cbp) es una enfermedad autoinmune multifactorial (factores genéticos, disparadores ambientales como localización geográfica, fumar, microorganismos, xenobióticos). El objetivo de este estudio es describir los factores de riesgo relacionados con colangitis biliar primaria y cómo incide en el riesgo cardiovascular. Se realizó búsqueda bibliográfica en bases de datos de investigaciones originales, estudios de cohorte prospectivo y retrospectivo, estudios de casos y controles, revisiones sistemáticas y metanálisis, en los que se utilizaron palabras claves relacionadas. Se encontró relación entre las alteraciones en la cbp con el perfil lipídico, el cual aumentaba el estrés oxidativo, disfunción endotelial; sin embargo, los estudios que tratan de determinar el efecto de la hipercolesterolemia sobre el aumento del rcv en paciente con cbp han sido contradictorios. La esteatosis hepática está relacionada con aumento de los ecv y es común en las enfermedades hepáticas crónicas como hepatitis B y C crónicas y la enfermedad hepática grasa no alcohólica. La cbp puede tener manifestaciones extrahepáticas, dentro de estas las más prevalentes son las pulmonares como la enfermedad pulmonar intersticial y la hipertensión pulmonar.Este artículo presenta la relación entre la cbp con sus principales factores de riesgo y el desarrollo de enfermedades tanto hepáticas como extrahepáticas que aumenta el riesgo cardiovascular.
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