Manifestaciones neurológicas por COVID-19. Reporte de casos en Hospital Militar Central Bogotá, Colombia, y revisión de la literatura

Resumen

Acorde a las fuentes epidemiológicas de la Organización Mundial de la Salud, en la última década, entre las principales causas de mortalidad más del 55 % resultaban de enfermedades no transmisibles, predominando la isquemia cardiaca y el accidente cerebrovascular como causales. En el 2019, con la aparición del nuevo coronavirus, COVID-19, como etiología de la pandemia que ha impactado tanto en salud como económica y socialmente al mundo, las cifras de la curva de las causas usuales de mortalidad han cambiado no solo a causa del efecto directo de la enfermedad en los múltiples órganos, sino también por los efectos indirectos en relación con falta de acceso a atención médica en enfermedades crónicas. Dado que es una enfermedad transmisible, el COVID-19 produce alteraciones, principalmente respiratorias y vasculares, sin embargo, el mayor conocimiento de los aspectos fisiopatológicos de la enfermedad ha revelado el compromiso de múltiples sistemas, destacando el sistema nervioso central como un objetivo del virus que impacta en las secuelas y los desenlaces de los pacientes, de modo que se documentan manifestaciones neurológicas hasta en un 55 %. El objetivo de esta revisión es caracterizar una serie de casos de pacientes en el Hospital Militar Central, mediante la descripción de aspectos fisiopatológicos y clínicos del compromiso neurológico

Biografía del autor/a

Lina María Lancheros Pineda, Universidad Militar Nueva Granada, Bogotá, Colombia

Médica residente Neurología, Universidad Militar Nueva Granada, Bogotá, Colombia.
Correo electrónico: linita_lancheritos@hotmail.com ORCID: https://orcid.org/0000-0002-2376-4535

Diana Alejandra Yasno Arias , Universidad Militar Nueva Granada, Bogotá, Colombia

Residente Neurología, Universidad Militar Nueva Granada, Bogotá, Colombia.
Corrreo electrónico: dianale03@gmail.com ORCID: https://orcid.org/0000-0001-8907-4871

Diana Isabel Zea Rojas

Residente Neurología, Universidad Militar Nueva Granada, Bogotá, Colombia.
Correo electrónico: dianisabzr88@gmail.com ORCID: https://orcid.org/0000-0003-2549-7079

Viviana Torres Ballesteros, Universidad Militar Nueva Granada, Bogotá, ColombiaNG

Residente Neurología, Universidad Militar Nueva Granada, Bogotá, Colombia.
Correo electrónico: vivito-ba2909@gmail.com ORCID: https://orcid.org/0000-0003-1795-0072

Oscar Bernal Pacheco, Hospital Militar Central. Bogotá, Colombia

Médico Neurólogo, sub especialista en Movimientos Anormales. Hospital Militar Central, Bogotá, Colombia.
Correo electrónico: oscarbernalp@gmail.com ORCID: https://orcid.org/0000-0001-6435-3137

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Biografía del autor/a

Lina María Lancheros Pineda, Universidad Militar Nueva Granada, Bogotá, Colombia

Médica residente Neurología, Universidad Militar Nueva Granada, Bogotá, Colombia.
Correo electrónico: linita_lancheritos@hotmail.com ORCID: https://orcid.org/0000-0002-2376-4535

Diana Alejandra Yasno Arias , Universidad Militar Nueva Granada, Bogotá, Colombia

Residente Neurología, Universidad Militar Nueva Granada, Bogotá, Colombia.
Corrreo electrónico: dianale03@gmail.com ORCID: https://orcid.org/0000-0001-8907-4871

Diana Isabel Zea Rojas

Residente Neurología, Universidad Militar Nueva Granada, Bogotá, Colombia.
Correo electrónico: dianisabzr88@gmail.com ORCID: https://orcid.org/0000-0003-2549-7079

Viviana Torres Ballesteros, Universidad Militar Nueva Granada, Bogotá, ColombiaNG

Residente Neurología, Universidad Militar Nueva Granada, Bogotá, Colombia.
Correo electrónico: vivito-ba2909@gmail.com ORCID: https://orcid.org/0000-0003-1795-0072

Oscar Bernal Pacheco, Hospital Militar Central. Bogotá, Colombia

Médico Neurólogo, sub especialista en Movimientos Anormales. Hospital Militar Central, Bogotá, Colombia.
Correo electrónico: oscarbernalp@gmail.com ORCID: https://orcid.org/0000-0001-6435-3137

Referencias Bibliográficas

Lu H, Stratton CW, Tang YW. Outbreak of pneumonia of unknown etiology in Wuhan, China: The mystery and the mirac. J Med Virol. 2020;92(4):401-2. DOI: https://doi.org/10.1002/jmv.25678

Chen N, Zhou M, Dong X, Qu J, Gong, F., Han Y, et al. Epidemiological and clinical characteristics of 99 cases

of 2019 novel coronavirus pneumonia in Wuhan, Chi- na: a descriptive study. Lancet. 2020;395(10223):507- 13. DOI: https://doi.org/10.1016/S0140-6736(20)30211-7

Papa SM, Brundin P, Fung VSC, Kang UJ, Burn DJ, Colosimo C, et al. Impact of the covid-19 Pandemic on Parkinson's Disease and Movement Disorders. Mov Disord. 2020;35(5):711-5. DOI: https://doi.org/10.1002/mds.28067

Lippi A, Domingues R, Setz C, Outeiro TF, Krisko A. SARS-CoV-2: At the Crossroad Between Aging and Neurodegeneration. Mov Disord. 2020;35(5):716-20. DOI: https://doi.org/10.1002/mds.28084

Costello F, Dalakas MC. Cranial Neuropathies and covid-19: Neurotropism and Autoimmunity. Neurology. 2020;95(5):195-6. DOI: https://doi.org/10.1212/WNL.0000000000009921

Ahmed MU, Hanif M, Ali MJ, Haider MA, Khe- rani D, Memon GM, et al. Neurological Manifes- tations of covid-19 (sars-cov-2): A Review. Front Neurol. 2020;11:518. DOI: https://doi.org/10.3389/fneur.2020.00518

Avula A, Nalleballe K, Narula N, Sapozhnikov S, Dan- du V, Toom S, et al. covid-19 presenting as stroke. Brain Behav Immune. 2020;87:115-119. DOI: https://doi.org/10.1016/j.bbi.2020.04.077

Khosravani H, Rajendram P, Notario L, Chapman MG, Menon BK. Protected Code Stroke: Hyperacute Stroke Management during the Coronavirus Disease 2019 (covid-19) Pandemic. Stroke. 2020;51(6):1891-1895. DOI: https://doi.org/10.1161/STROKEAHA.120.029838

Nguyen TN, Abdalkader M, Jovin TG, Nogueira R, Jadahav A, Hausse D, et al. Mechanical Thrombectomy in the Era of the covid-19 Pandemic: Emergency Preparedness for Neuroscience Teams: A Guidance Statement From the Society of Vascular and Interventional Neurology. Stroke. 2020;51(6):1896-901. DOI: https://doi.org/10.1161/STROKEAHA.120.030629

Romoli M, Jelcic I, Bernard-Valnet R, García Azorín D, Mancinelli L, Akhvlediani T, et al. A Systematic Review of Neurological Manifestations of SARS-CoV-2 Infection: The Devil is Hidden in the Details. Eur J Neurol. 2020;10:1111.

Reddy ST, Reddy ST, Garg T, Shah C, Nascimento FA, Imran R, et al. Cerebrovascular Disease in Patients with covid-19: A Review of the Literature and Case Series. Case Rep Neurol. 2020;12(2):199-209. DOI: https://doi.org/10.1159/000508958

Benussi A, Pilotto A, Premi E, Libri I, Giunta M, Agosti C, et al. Clinical Characteristics and Outcomes of

Manifestaciones neurológicas por covid-19. Reporte de casos en Hospital Militar Central Bogotá, Colombia, y revisión de la literatura inpatients with neurologic disease and covid-19 in Brescia, Lombardy, Italy. Neurology. 2020;10:1212. DOI: https://doi.org/10.1212/WNL.0000000000009848

Yaghi S, Ishida K, Torres J, Mac Grory B, Raz E, Humbert K, et al. sars-cov-2 and Stroke in a New York Healthcare System. Stroke. 2020;51(7):2002-11. DOI: https://doi.org/10.1161/STROKEAHA.120.030335

Mao L, Jin H, Wang M, Hu Y, Chen S, He Q, et al. Neurologic Manifestations of Hospitalized Patients with Coronavirus Disease 2019 in Wuhan, China. JAMA Neurol. 2020;77(6):1-9. DOI: https://doi.org/10.1001/jamaneurol.2020.1127

Beyrouti R, Adams ME, Benjamin L et al. Characteristics of ischaemic stroke associated with covid-19. J Neurol Neurosurg Psychiatry. 2020;91:889-91. DOI: https://doi.org/10.1136/jnnp-2020-323586

Ellul MA, Benjamin L, Singh B, Lant S, Michael BD, Easton A, et al. Neurological associations of covid-19. Lancet Neurol. 2020;19(9):767-83. DOI: https://doi.org/10.1016/S1474-4422(20)30221-0

WangL,ShenY,LiM,ChuangH,YeY,ZhaoH,etal. Clinical manifestations and evidence of neurological involvement in 2019 novel coronavirus SARS-Cov-2: a systematic review and meta-analysis. J Neurol. 2020;11:1-13. DOI: https://doi.org/10.1007/s00415-020-09974-2

Payus AO, Lin CLS, Noh MM, Jeffree MS, Ali RA. SARS-CoV-2 infection of the nervous system: A review of the literature on neurological involvement in novel coronavirus disease-( covid-19). Bosn J Basic Med Sci. 2020;20(3):283-92. DOI: https://doi.org/10.17305/bjbms.2020.4860

Wu Y, Xu X, Chen Z, Duan J, Hashimoto K, Yang L. Nervous system involvement after infection with covid-19 and other coronaviruses. Brain Behav Immun. 2020;87:18-22. DOI: https://doi.org/10.1016/j.bbi.2020.03.031

Bridwell R, Long B GM. Neurologic complications of covid-19. Am J Emerg Med. 2020;38(7):1-5. DOI: https://doi.org/10.1016/j.ajem.2020.05.024

Romero-Sánchez CM, Díaz-Maroto I, Fernández-Díaz E, Sánchez-Larsen Á, Layos-Romero A, García-García J, et al. Neurologic manifestations in hospitalized patients with covid-19: The albacovid registry. Neurology. 2020;10:1212.

Román G, Spencer P, Reis J, Buguet A, Faris M, Katrak S, et al. The Neurology of covid-19 Revisited: A Proposal from the Environmental Neurology Specialty Group of the World Federation of Neurology to Implement International Neurological Registries. J Neurol Sci. 2020;414(4):116884. DOI: https://doi.org/10.1016/j.jns.2020.116884

Pryce-Roberts A, Talaei M, Robertson N. Neurological complications of COVID-19: a preliminary review. J Neurol. 2020;267(6):1870-3. DOI: https://doi.org/10.1007/s00415-020-09941-x

Moshayedi P, Ryan TE, Mejia LLP, Nour M, Liebeskind DS. Triage of Acute Ischemic Stroke in Confirmed co- vid-19: Large Vessel Occlusion Associated With Coro- navirus Infection. Front Neurol. 2020;11(April):10-2. DOI: https://doi.org/10.3389/fneur.2020.00353

Spence J, de Freitas G., Pettigrew L, Ay H, Liebeskind D, Kase C, et al. Mechanisms of Stroke in covid-19. Cerebrovasc Dis. 2020;20(7):1-8.

Oxley TJ, Mocco J, Majidi S et al. Large-Vessel Stroke as a Presenting Feature of covid-19 in the Young. N Engl J Med. 2020;382(20):60. DOI: https://doi.org/10.1056/NEJMc2009787

Fan H, Tang X, Song Y, Liu P, Chen Y. Influence of covid-19 on cerebrovascular disease and its possible mechanism. Neuropsychiatr Dis Treat. 2020;16:1359- 67. DOI: https://doi.org/10.2147/NDT.S251173

Sheraton M, Deo N, Kashyap R, Surani S. A Review of Neurological Complications of covid-19. Cureus. 2020;2(5):8192. DOI: https://doi.org/10.7759/cureus.8192

Jin H, Hong C, Chen S, Zhou Y, Wang Y, Mao L, et al. Consensus for Prevention and management of coronavirus disease 2019 (covid-19) for neurologists. Stroke Vasc Neurol. 2020;5(2):146-51. DOI: https://doi.org/10.1136/svn-2020-000382

Divani A, Andalib S, Napoli M, Lattanzi S, Hus- sain M, Mccullough L, et al. Coronavirus Disease 2019 and Stroke: Clinical Manifestations and Pathophysiological Insights. J Stroke Cerebrovasc Dis. 2020;29(8):104941. DOI: https://doi.org/10.1016/j.jstrokecerebrovasdis.2020.104941

Montalvan V, Lee J, Bueso T, De Toledo J, Rivas K. Neurological manifestations of covid-19 and other coronavirus infections: A systematic review. Clin Neurol Neurosurg. 2020;194(7):105921. DOI: https://doi.org/10.1016/j.clineuro.2020.105921

aha/asa Stroke Council Leadership. Temporary Emergency Guidance to us Stroke Centers During the Coronavirus Disease 2019 (covid-19) Pandemic: On Behalf of the American Heart Association/Ame- rican Stroke Association Stroke Council Leadership. Stroke. 2020;51(6):1910-2. DOI: https://doi.org/10.1161/STROKEAHA.120.030023

Han Y, Zeng H, Jiang H, Yang Y, Yuan Z, Cheng X, et al. csc Expert Consensus on Principles of Clinical Manage- ment of Patients with Severe Emergent Cardiovascular Diseases during the covid-19 Epidemic. Circulation. 2020;141(20):810-6. DOI: https://doi.org/10.1161/CIRCULATIONAHA.120.047011

Dafer R, Osteraas N, Biller J. Acute Stroke Care in the Coronavirus Disease 2019 Pandemic. J Stroke Cerebrovasc Dis. 2020;29(7):104881. DOI: https://doi.org/10.1016/j.jstrokecerebrovasdis.2020.104881

Meyer D, Meyer B, Rapp K, Modir R, Agrawal K, Hailey L, et al. A Stroke Care Model at an Academic, Comprehensive Stroke Center During the 2020 covid-19 Pandemic. J Stroke Cerebrovasc Dis. 2020; 29(8):104927. DOI: https://doi.org/10.1016/j.jstrokecerebrovasdis.2020.104927

De Silva D, Tan I, Thilarajah S. A protocol for acute stroke unit care during the covid-19 pandemic. J Stroke Cerebrovasc Dis. 2020;29(9):105009. DOI: https://doi.org/10.1016/j.jstrokecerebrovasdis.2020.105009

Sedaghat Z, Karimi N. Guillain Barre syndrome associated with covid-19 infection: A case report. J Clin Neurosci. 2020;76(6):233-5. DOI: https://doi.org/10.1016/j.jocn.2020.04.062

Toscano G, Palmerini F, Ravaglia S et al. Guillain-Barré Syndrome Associated with sars-cov-2. N Engl J Med. 2020;382(26):2574-6. DOI: https://doi.org/10.1056/NEJMc2009191

Alberti P, Beretta S, Piatti M, Karantzoulis A, Piat- ti ML, Santoro P, et al. Guillain-Barré syndrome reLated to covid-19 infection. Neurol Neuroimmunol NeuroInflammation. 2020;7(4):741. DOI: https://doi.org/10.1212/NXI.0000000000000741

Chan M, Han S, Kelly S, Tamimi M, Giglio B, Lewis A. A case series of Guillain-Barré Syndrome Following covid-19 Infection in New York. Neurol Clin Pract. 2020;10.1212/CP. DOI: https://doi.org/10.1212/CPJ.0000000000000880

Gutiérrez-Ortiz C, Méndez A, Rodrigo-Rey S, San Pedro-Murillo E, Bermejo-Guerrero L, Gordo-Mañas R, et al. Miller Fisher Syndrome and polyneuritis cranialis in covid-19. Neurology. 2020;95(5):601-5. DOI: https://doi.org/10.1212/WNL.0000000000009619

Manganotti P, Pesavento V, Buoite Stella A, Bonzi L, Campagnolo E, Bellavita G, et al. Miller Fisher syndrome diagnosis and treatment in a patient with sars-cov-2. J Neurovirol. 2020;1-2. DOI: https://doi.org/10.1007/s13365-020-00858-9

Casas E, Barbosa A, Rubio-García E, Cebrián J, Díaz-Pérez C, de la Fuente E, et al. Isolated peripheral facial paralysis in a patient with covid-19. Rev Neurol. 2020;71(1):40-1. DOI: https://doi.org/10.33588/rn.7101.2020229

Kobylecki C, Jones T, Lim C, Miller C, Thomson A. Phenomenology and outcomes of in‐patients with Parkinson's disease during covid-19 pandemic. Mov Di- sord. 2020;35(8):1295-6. DOI: https://doi.org/10.1002/mds.28205

Zhang J, Hu W, Chen H, Meng F, Li L, Okun MS. Implementation of a Novel Bluetooth Technology for Remote Deep Brain Stimulation Programming: The Pre- and Post-covid-19 Beijing Experience. Mov Disord. 2020;35(6):909-10. DOI: https://doi.org/10.1002/mds.28098

Goetz CG, Stebbins GT, Luo S. Movement Disorder Society-Unified Parkinson's Disease Rating Scale Use in the covid-19 Era. Mov Disord. 2020;35(6):911. DOI: https://doi.org/10.1002/mds.28094

Salari M, Zali A, Ashrafi F, Etemadifar M, Sharma S, Hajizadeh N, et al. Incidence of Anxiety in Parkinson's Disease During the Coronavirus Disease (covid-19) Pandemic. Mov Disord. 2020;35(7):1095-6. DOI: https://doi.org/10.1002/mds.28116

Vollono C, Rollo E, Romozzi M, Frisullo G, Servidei S, Borghetti A, et al. Focal Status Eepilepticus as Unique Clinical Feature of covid-19: a Case Report. Seizure. 2020;78:109-12. DOI: https://doi.org/10.1016/j.seizure.2020.04.009

Elgamasy S, Kamel MG, Ghozy S, Khalil A, Morra ME, Islam sms. First Case of Focal Epilepsy Associated with SARS Coronavirus-2. J Med Virol. DOI: https://doi.org/10.1002/jmv.26113

Libbey JE, Kirkman NJ, Smith MCP, Tanaka T, Wilcox KS, White HS, et al. Seizures Following Picornavirus Infection. Epilepsia. 2008;49(6):1066-74. DOI: https://doi.org/10.1111/j.1528-1167.2008.01535.x

Hepburn M, Mullaguri N, George P, Hantus S, Punia V, Bhimraj A, et al. Acute Symptomatic Seizures in Critically Ill Patients with covid-19: Is There an Association? Neurocrit Care. 2020;1-5. DOI: https://doi.org/10.1007/s12028-020-01006-1

Cabezudo-García P, Ciano-Petersen NL, Mena-Váz- quez N, Pons-Pons G, Castro-Sánchez MV, Serra- no-Castro PJ. Incidence and Case Fatality Rate of covid-19 in Patients with Active Epilepsy. Neurology. 2020;10.1212/WN. DOI: https://doi.org/10.1212/WNL.0000000000010033

Lu L, Xiong W, Liu D, Liu J, Yang D, Li N, et al. New Onset Acute Symptomatic Seizure and Risk Factors in Coronavirus Disease 2019: A Retrospective Multicenter Study. Epilepsia. 2020;61(6):49-e53. DOI: https://doi.org/10.1111/epi.16524

Kuroda N. Epilepsy and COVID-19: Associations and Important Considerations. Epilepsy Behav. 2020;108:107122. DOI: https://doi.org/10.1016/j.yebeh.2020.107122

Pati S, Houston T. Assessing the Risk of Seizures with Chloroquine or Hydroxychloroquine Therapy for covid-19 in Persons with Epilepsy. Epilepsy Res. 2020;165:106399. DOI: https://doi.org/10.1016/j.eplepsyres.2020.106399

Kwan P, Arzimanoglou A, Berg A, Brodie M, Hauser W, Mathern G, et al. Definition of Drug Resistant Epilepsy: Consensus Proposal by the ad hoc Task Force of the ilae Commission on Therapeutic Strategies. Epilepsia. 2010;51(6):1069-77. DOI: https://doi.org/10.1111/j.1528-1167.2009.02397.x

Olesen J. Headache Classification Committee of the International Headache Society (IHS) The International Classification of Headache Disorders, 3rd edition. Cephalalgia. 2018;38(1):1-211. DOI: https://doi.org/10.1177/0333102417738202

Yachou Y, El Idrissi A, Belapasov V, Ait S. Neuroinvasion, neurotropic, and neuroinflammatory events of SARS-CoV-2: understanding the neurological manifestations in covid-19 patients. Neurol Sci. 2020;1-13. DOI: https://doi.org/10.1007/s10072-020-04575-3

Moore JB, June CH. Cytokine release syndrome in severe covid-19. Science (80-). 2020;368(6490):473-4. DOI:

https://doi.org/10.1126/science.abb8925

Benemei S, Dussor G. trp channels and migraine: Recent developments and new therapeutic opportunities. Pharmaceuticals. 2019;12(2):1-17. DOI: https://doi.org/10.3390/ph12020054

Baig A, Khaleeq A, Ali U, Syeda H. Evidence of the covid-19 Virus Targeting the CNS: Tissue Distribution, Host-Virus Interaction, and Proposed Neurotropic Mechanisms. acs Chem Neurosci. 2020;11(7):995-8. DOI: https://doi.org/10.1021/acschemneuro.0c00122

Bolay H, Gül A, Baykan B. covid-19 is a Real Headache! Headache. 2020;10.1111/he. DOI: https://doi.org/10.1111/head.13856

Borges do Nascimento IJ, Cacic N, Abdulazeem HM, von Groote TC, Jayarajah U, Weerasekara I, et al. No- vel Coronavirus Infection (covid-19) in Humans: A Scoping Review and Meta-Analysis. J Clin Med. 2020;9(4):941. DOI: https://doi.org/10.3390/jcm9040941

Whittaker A, Anson M, Harky A. Neurological Mani- festations of covid-19: A Systematic Review and Current Update. Acta Neurol Scand. 2020;142(1):14-22. DOI: https://doi.org/10.1111/ane.13266

Maassenvandenbrink A, De Vries T, Danser AHJ. Headache Medication and the covid-19 Pandemic. J Headache Pain. 2020;21(1):1-4. DOI: https://doi.org/10.1186/s10194-020-01106-5

Katal S, Balakrishnan S, Gholamrezanezhad A. Neuroimaging and Neurologic Findings in covid-19 and Other Coronavirus Infections: A Systematic Review in 116 Patients. J Neuroradiol. 2020;S0150- 9861(20):30204-2.

Kremer S, Lersy F, Anheim M, Merdji H, Schenck M, Oesterlé H, et al. Neurologic and Neuroimaging Findings in covid-19 Patients: A Retrospective Multicenter Study. Neurology. 2020;10.1212/WN.

Carod-Artal FJ. Neurological complications of coronavirus and covid-19. Rev Neurol. 2020;70(9):311- 22. DOI: https://doi.org/10.33588/rn.7009.2020179

Moriguchi T, Harii N, Goto J, Harada D, Sugawara H. Since January 2020 Elsevier has created a covid-19 resource centre with free information in English and Mandarin on the novel coronavirus covid-19. The covid-19 resource centre is hosted on Elsevier Connect, the company' s public news and information. 2020;(en).

Poyiadji N, Shahin G, Noujaim D, Stone M, Patel S GB. covid-19-associated Acute Hemorrhagic Necrotizing Encephalopathy: Imaging Features. Radiology. 2020;296(2):119-20. DOI: https://doi.org/10.1148/radiol.2020201187

Cómo citar
Lancheros Pineda, L. M., Yasno Arias , D. A., Zea Rojas , D. I., Torres Ballesteros, V., & Bernal Pacheco, O. (2021). Manifestaciones neurológicas por COVID-19. Reporte de casos en Hospital Militar Central Bogotá, Colombia, y revisión de la literatura. Revista Med, 29(1), 57-76. https://doi.org/10.18359/rmed.5144
Publicado
2021-12-31
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