Motivos C-terminales de gp41 del VIH-1 como posibles determinantes de la patogénesis viral

Resumen

El virus de la inmunodeficiencia humana tipo 1 (VIH-1) es el agente etiológico del síndrome de inmunodeficiencia adquirida (SIDA), una pandemia con altos costos económicos y sociales. La glicoproteína de la envoltura (env) del virus media el proceso infeccioso al unirse a la célula huésped y entrar en ella, uno de los principales componentes objetivo de los estudios desde su descubrimiento. Su endodominio o cola C-terminal (CTT) participa en procesos tardíos del ciclo replicativo, como tráfico intracelular, activación y muerte celular, lo que ocurre porque interactúa con múltiples factores celulares a través de motivos o secuencias señal presentes en toda su estructura. Aunque estas interacciones no se han entendido completamente a niveles específicos, los estudios durante más de tres décadas no dejan dudas de que este campo juega un papel fundamental en la biología del virus y probablemente en el desarrollo de la enfermedad. Esta revisión describe los estudios realizados hasta la fecha que demuestran la importancia de la CTT, centrándose en los motivos responsables de sus interacciones y sus posibles roles en la patogenicidad de la infección.

Biografía del autor/a

Jorge Andrés Narváez-Pardo, Universidad del Atlántico, Barranquilla, Colombia

BS Biology. Basic Sciences School, Biology Program, Universidad del Atlántico, Barranquilla, Colombia. 
E-mail: jandresnarvaez@gmail.com orcid: https://orcid.org/0000-0001-7437-8987 

José-Luis Villarreal, Universidad Libre, Barranquilla, Colombia

BS Microbiology. Health Sciences School, Medicine Program, Universidad Libre, Barranquilla, Colombia. 
E-mail: josel.villarrealc@unilibre.edu.co orcid: https://orcid.org/0000-0002-7240-7462 

Lourdes Luz Varela Prieto, Universidad del Atlántico, Barranquilla, Colombia

Basic Sciences School, Biology Program, Universidad del Atlántico, Barranquilla, Colombia. 
E-mail: lourdesvarela@mail.uniatlantico.edu.co orcid: https://orcid.org/0000-0001-6000-3113 

Guillermo Cervantes-Acosta, Universidad del Norte, Barranquilla, Colombia

PhD Virology and Immunology. MS Microbiology. BS Pharmaceutical Chemistry, Medicine Department, Universidad del Norte, Barranquilla, Colombia.
E-mail: guicerva@uninorte.edu.co ORCID: https://orcid.org/0000-0002-6359-9554

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Biografía del autor/a

Jorge Andrés Narváez-Pardo, Universidad del Atlántico, Barranquilla, Colombia

BS Biology. Basic Sciences School, Biology Program, Universidad del Atlántico, Barranquilla, Colombia. 
E-mail: jandresnarvaez@gmail.com orcid: https://orcid.org/0000-0001-7437-8987 

José-Luis Villarreal, Universidad Libre, Barranquilla, Colombia

BS Microbiology. Health Sciences School, Medicine Program, Universidad Libre, Barranquilla, Colombia. 
E-mail: josel.villarrealc@unilibre.edu.co orcid: https://orcid.org/0000-0002-7240-7462 

Lourdes Luz Varela Prieto, Universidad del Atlántico, Barranquilla, Colombia

Basic Sciences School, Biology Program, Universidad del Atlántico, Barranquilla, Colombia. 
E-mail: lourdesvarela@mail.uniatlantico.edu.co orcid: https://orcid.org/0000-0001-6000-3113 

Guillermo Cervantes-Acosta, Universidad del Norte, Barranquilla, Colombia

PhD Virology and Immunology. MS Microbiology. BS Pharmaceutical Chemistry, Medicine Department, Universidad del Norte, Barranquilla, Colombia.
E-mail: guicerva@uninorte.edu.co ORCID: https://orcid.org/0000-0002-6359-9554

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Cómo citar
Narváez-Pardo, J. A., Villarreal, J.-L., Varela Prieto, L. L., & Cervantes-Acosta, G. (2022). Motivos C-terminales de gp41 del VIH-1 como posibles determinantes de la patogénesis viral. Revista Med, 29(2), 107-120. https://doi.org/10.18359/rmed.5850
Publicado
2022-08-01
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