Alleles -108C/T, L55M and Q192R of Paraoxonase 1 (PON 1) in a Population of the Colombian Coffee Region
Abstract
Abstract: Paraoxonase 1 (PON 1) is an enzyme integrated into high-density lipoproteins (HDL); its activity has been associated with the antioxidant effect of these lipoproteins. A reduced activity of these is associated with cardiovascular disease. The activity of the enzyme seems to depend on its polymorphisms (C-108T, L55M and Q192R), which makes them responsible for inter-individual and interethnic
variability. Objective: to genotypically characterize the PON 1 polymorphisms in the Colombian mestizo population. Methods: the frequencies of the alleles rs705379 (-108 C/T), rs 854560 (L55M) and rs 662 (Q192R) of the PON 1 gene were determined in 133 healthy adults, with mestizo traits, of non-consanguineous subjects of both sexes. Genotyping was done by mini-sequencing (SnaPshot).
Results: the frequencies of the polymorphic genotypes were: -108 C/T (CC 34%, CT 45%, TT 21%), L55M (LL 50%, LM 43%, MM 7%) and Q192R (QQ 42%, QR 50%, RR 8%). Six individuals (4.5%) had native triple homozygous haplotype (CC/CC/AA). Conclusion: the results indicate that in the population studied, the genotypic frequencies were not different from those described for other Latin American
and European populations. Furthermore, no strong link was observed between the three loci studied.
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References
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