Radiocirurgia no glioblastoma: uma revisão da literatura
Resumo
O manejo de gliomas de alto grau, particularmente o glioblastoma, continua sendo um desafio apesar dos avanços na terapia de radiação e cirurgia. O cuidado padrão envolve a ressecção cirúrgica máxima, seguida de radioterapia e quimioterapia com Temozolomida. A Radiocirurgia Estereotáxica com Gamma Knife (GKRS) surgiu como uma opção não invasiva e eficaz para tratar
uma variedade de lesões do sistema nervoso central. A GKRS oferece uma entrega precisa de radiação de baixa energia a um alvo definido, induzindo a destruição do tecido enquanto preserva o tecido cerebral saudável. Embora efeitos secundários como necrose por radiação tenham sido observados, a GKRS mostra promessas no tratamento do glioblastoma, mesmo com sua natureza
infiltrativa. Esta revisão explora o panorama evolutivo do manejo de gliomas de alto grau, com foco no potencial da GKRS para melhorar os resultados do tratamento.
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