Streptococcus agalactiae e susceptibilidade em gestantes de um hospital em Palmira, no departamento do Valle
Resumo
Streptococcus agalactiae, também conhecido como estreptococo do grupo B, é uma bactéria gram-positiva, saprófita, colonizadora do trato gastrointestinal e geniturinário, causando infecções principalmente em recém-nascidos, gestantes e, raramente, em adultos com doenças subjacentes. A presença desse microrganismo pode ser uma causa significativa de corioamnionite e
endometrite pós-parto. Este estudo descreverá a susceptibilidade do S. agalactiae em gestantes que
estiveram no serviço de obstetrícia em um hospital de nível II em Palmira, no período de 1 de janeiro de 2018 a 31 de dezembro de 2019, através de um estudo descritivo retrospectivo. Foram obtidos 58 cultivos retovaginais positivos para S. agalactiae por meio de amostras com cotonetes vaginal e retal, dados fornecidos pelo laboratório do Hospital Raúl Orejuela Bueno. O teste de susceptibilidade antimicrobiana foi realizado utilizando o método automatizado VITEK-2. Nos 58 cultivos retovaginais positivos para Streptococcus agalactiae, foi observada uma sensibilidade de 100% à ampicilina, levofloxacino e moxifloxacino; 98% à quinupristina, linezolida e vancomicina sensível.
Downloads
Referências
Delgado-Arévalo KJ, González-Habib R. Tamizaje del estreptococo del grupo B durante el embarazo: conducta actual en un centro de tercer nivel. Ginecol Obstet Mex. 2020;88(02):127-129. https://doi.org/10.24245/gom.v88i2.3716
do Nascimento, CS et al. Streptococcus Agalactiae in Pregnant Women in Brazil: Prevalence, Serotypes, and Antibiotic Resistance. Braz J Microbiol. 2019 Feb;50: 943-952. https://doi.org/10.1007/s42770-019-00129-8
Baron Barshak M, Madoff Lawrence C. Group B Streptococcal Infections in Nonpregnant Adults. UpToDate;2022, Disponible en: https://www.uptodate.com/contents/group-b-streptococcal-infections-in-nonpregnant-adults?search=stre
Poupolo KM, Madoff LC. Group B Streptococcal Infection in Pregnant Individuals. UpToDate;2022. Disponible en: https://www.uptodate.com/contents/group-b-streptococcal-infection-in-pregnant-individuals?search=s%20treptococcus%20agalactiae&source=search_result&selectedTitle=2~150&usage_type=default&display_rank=2
Madoff LC. Estreptococo del grupo B: factores de virulencia y mecanismos patogénicos. UpToDate;2022.Disponible en:https://www.uptodate.com/contents/group-b-streptococcus-virulence-factors-and-pathogenic-mechanisms?search=streptococcus%20agalactiae&source=search_result&selectedTitle=5~150&usage_type=default&display_rank=5
Baker CJ. Prevention of Early-Onset Group B Streptococcal Disease in Neonates, UpToDate; 2022. Disponible en: https://www.uptodate.com/contents/prevention-of-early-onset-group-b-streptococcal-disease-in-neonates?search=streptococcus%20agalactiae&source=search_result&selectedTitle=4~150&usage_type=default&display_rank=4
Poupolo KM, Baker CJ. Management of Neonates at Risk for Early-Onset Group B Streptococcal Infection.UpToDate; 2022. https://www.uptodate.com/contents/management-of-neonates-at-risk-for-early-onset-group-b-streptococcal-infection
Rajack F, et al. An Emerging Infection: Streptococcal Toxic Shock-Like Syndrome Caused by Group B Streptococcus (GBS), Streptococcus Agalactiae. American Journal of Clinical Pathology. 2020;154(1):S140. https://doi.org/10.1093/ajcp/aqaa161.306
Furfaro LL, Chang Barbara J. Perinatal Streptococcus agalactiae Epidemiology and Surveillance Targets. Clin Microbiol Rev. 2018 Ago 15;31(4):e00049-18. https://doi.org/10.1128/CMR.00049-18
Lopardo, HÁ, Berardinelli EM. Estreptococos del grupo Streptococcus anginosus Parte II. Patogenia y sensibilidad a los antibióticos. Acta Bioquímica Clínica Latinoamericana. 2021;55(1):61-77. Disponible en: https://www.redalyc.org/journal/535/53566167011/html/
Duarte C, et al. Streptococcus Pneumoniae Serotype 3 Genotypes in Invasive Isolates from Colombia. Biomédica. 2021 Jun 29;41(2):338-346. https://doi.org/10.7705/biomedica.5407
Renato de Ávila K; Pignatari, Antônio Carlos Campos, Capsular genotype distribution of Group B Streptococcus colonization among at-risk pregnant women in Sao Paulo, Brazil. Braz J Infect Dis. 2021 May-Jun;25(3):101586. https://doi.org/10.1016/jbjid.2021.101586
Verani JR, et al. Prevention of Perinatal Group B Streptococcal Disease Revised Guidelines from CDC.MMWR Recomm Rep. 2010 Nov 19;59(RR-10):1-36.PMID: 21088663
Melo SCCS de, et al. Prevalence of Streptococcus agalactiae Colonization in Pregnant Women from the 18th Health Region of Paraná State. Rev. Inst.Med. trop. 2018;60:e2. https://doi.org/10.1590/S1678-9946201860002
Gizachew M, et al. Streptococcus agalactiae from Ethiopian Pregnant Women; Prevalence, Associated Factors and Antimicrobial Resistance: Alarming for Prophylaxis. Ann Clin Microbiol Antimicrob. 2019;18(3):1-9. https://doi.org/10.1186/s12941-019-0303-3
Committee Opinion, Early-Onset Group B Streptococcal Disease. Obstet Gynecol. 2020 Feb;135(2):e51-e72.17. Edwards MS, Baker CJ. Streptococcus agalactiae (Group B Streptococcus). En GL Mandell, JE Bennett, R Dolin. (eds.). Principles & Practice of Infectious Diseases. Vol. 2, 7a. ed. Filadelfia: Elsevier; 2010. p. 2655-66. Chapter 202.
Edwards MS, Nizet V. Group B streptococcal infections. En: JS Remington, JO Klein, CB Wilson, V Nizet V, YA Maldonado YA. (eds.). Infectious Diseases of the Fetus and Newborn Infant. 7a. ed. Filadelfia: Elsevier;2011. p. 419-69.
Verani JR, Schrag SJ. Group B Streptococcal Disease in Infants: Progress in Prevention and Continued Challenges. Clin Perinatol. 2010 Jun;37(2):375-92. https://doi.org/10.1016/j.clp.2010.02.002
Stoll BJ, et al. Early Onset Neonatal Sepsis: The Burden of Group B Streptococcal and E. Coli Disease Continues. Pediatrics. 2011;127(5):817-26. https://doi.org/10.1542/peds.2010-2217
Herbert MA, Beveridge CJE, Saunders NJ. Bacterial virulence factors in neonatal sepsis: group B Streptococcus.Curr Opin Infect Dis. 2004 Jun;17(3):225-9.https://do.org/10.1097/00001432-200406000-00009
Burnham CA, Tyrrell GJ. Virulence factors of group B streptococci. Rev. Med Microbiol 2003;14:109-18. https://doi.org/10.1097/00013542-200310000-00002
Le Doare K, Heath P. An overview of global GBS epidemiology.Vaccine. 2013 Aug 28;31 Suppl 4:D7-12.https://doi.org/10.1016/j.vaccine.2013.01.009
Schrag S. Prevention of Perinatal Group B Streptococcal Disease. Revised Guidelines from CDC. MMWR Recomm Rep. 2002 Ago 16;51(RR-11):1-22. PMID:12211284
De Mouy D, et al. AFICORPI-BIO Network. Antibiotic Susceptibility and Mechanisms of Erythromycin Resistance in Clinical Isolates of Streptococcus agalactiae:French Multicenter Study. Antimicrob Agents Chemother. 2001 Ago;45(8):2400-2. https://doi.org/10.1128/AAC.45.8.2400-2402.2001
Uh Y, et al. Emerging Erythromycin Resistance among Group B Streptococci in Korea. Eur J Clin Microbiol Infect Dis. 2001 Ene;20(1):52-4. https://doi. org/10.1007/s100960000414
Schrag S, et al. Prevention of Perinatal Group B Streptococcal Disease Revised Guidelines from CDC.MMWR Recomm Rep 2002 Ago 16;51(RR-11):1-22.PMID: 12211284
Chiao WL, et al. Serotype Distribution and Clinical Correlation of Streptococcus agalactiae Causing Invasive Disease in Infants and Children in Taiwan. Journal of Microbiology, Immunology and Infection. 2019 Ago;52(4):578-584. https://doi.org/10.1016/j.jmii.2017.09.002
Weisner AM, et al. Characterization of group B streptococci Recovered from Infants with Invasive Disease in England and Wales. Clin Infect Dis. 2004 May 1;38(9):1203-8. https://doi.org/10.1086/382881
Zaleznik DF, et al. Invasive Disease due to Group B Streptococcus in Pregnant Women and Neonates from Diverse Population Groups. Clin Infect Dis. 2000 Feb;30(2):276-81. https://doi.org/10.1086/313665
Hooven TA, et al. The Streptococcus agalactiae Stringent Response Enhances Virulence and Persistence in Human Blood. ASM Journals Infection and Immunity, 2018;86(1): https://doi.org/10.1128/IAI.00612-17
Martínez Sánchez LM, et al. Prevención de la infección por Streptococcus del grupo B. Med UNAB. 2017 Ago-Nov;20(2):182-189. https://doi.org/10.29375/01237047.2308
Sociedad Latinoamericana de Infectología Pediátrica. Opinión de expertos sobre Infecciones Congénitas y Perinatales (ICP) SLIPE‐2014. Disponible en: http://www.slipe.org/informesAcademicos.asp
Verani JR, et al. Division of Bacterial Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention (CDC). Prevention of Perinatal Group B Streptococcal Disease--Revised Guidelines from CDC, 2010.MMWR Recomm Rep. 2010 Nov 19;59(RR-10):1-36.PMID: 21088663
Pannaraj PS, Baker CJ. Group B Streptococcal Infections. En: JD Cherry, WJ Steinbach, GJ Harrison, et al.(eds.). Feigin and Cherry’s Textbook of Pediatric Infectious Diseases. 7th ed. Filadelfia: Elsevier Saunders;2014. p. 1153-69.
Palacios Saucedo GC, et al. Infección perinatal por estreptococo del grupo B: Panorama global, en América Latina y en México. Gac Med Mex. 2017;153(3):361-370. Disponible en: https://www.medigraphic.com/cgi-bin/new/resumen.cgi?IDARTICULO=74777
Villaseñor-Sierra A, et al.Prevalencia de Streptococcus agalactiae del serotipo III en embarazadas.Ginecol Obstet Mex.2004;72:103-8.Disponible en:https://ginecologiayobstetricia.org.mx/articulo/prevalencia-de-streptococcus-agalactiae-del-serotipo-iii-en-embarazadas
Faro J. More Rapid Testing Group B Streptococcus Detection.MLO Med Lab Obs. 2013 Jun;45(6):15. PMID:23875438 39. Park JS, et al. Usefulness of a Rapid Real-Time PCR Assay in Prenatal Screening for Group B Streptococcus Colonization. Ann Lab Med. 2013 Ene;33(1):39-44.https://doi.org/10.3343/alm.2013.33.1.39
Yancey MK, et al. The Accuracy of Late Antenatal Screening Cultures in Predicting Genital Group B Streptococcal Colonization at Delivery. Obstet Gynecol. 1996 Nov;88(5):811-5. https://doi.org/10.1016/0029-7844(96)00320-1
Alós Cortés JI, et al. Prevención de la infección perinatal por estreptococo del grupo B. Recomendaciones españolas. Actualización 2012. Documento de consenso SEIMC/SEGO/SEN/SEQ/SEMFYC. Enferm Infecc Microbiol Clin. 2013;31(3):159-172. https://doi.org/10.1016/j.eimc.2012.03.013
Fay K, et al. Antenatal and Intrapartum Nucleic Acid Amplification Test use for Group B Streptococcus Screening United States, 2016. Diagn Microbiol Infect Dis. 2019 Jun;94(2):157-159. https://doi.org/10.1016/j.diagmicrobio.2018.11.026
Melin P. Neonatal Group B Streptococcal Disease:from Pathogenesis to Preventive Strategies. Clin Microbio Infect. 2011 Sep;17(9):1294-303. https://doi.org/10.1111/j.1469-0691.2011.03576.x
Kimura K, et al. Active Screening of Group B Streptococci with Reduced Penicillin Susceptibility and Altered Serotype Distribution Isolated from Pregnant Women in Kobe, Japan. Jpn J Infect Dis. 2013;66(2):158-60 https://doi.org/10.7883/yoken.66.158
Capanna F, et al. Antibiotic Resistance Patterns among Group B Streptococcus Isolates: Implications for Antibiotic Prophylaxis for Early-Onset Neonatal Sepsis.Swiss Med Wkly. 2013 Mar 25;143:w13778. https://doi.org/10.4414/smw.2013.13778
Nanduri SA, et al. Epidemiology of Invasive Early-Onset and Late-Onset Group B Streptococcal Disease in the United States, 2006 to 2015: Multistate Laboratory and Population-Based Surveillance [preprint]. JAMA Pediatr. 2019 Mar 1;173(3):224-233. https://doi.org/10.1001/jamapediatrics.2018.4826
Creti R, et al. Italian Neonatal GBS Infections Working Group. Neonatal Group B Streptococcus Infections: Prevention Strategies, Clinical and Microbiologic Characteristics in 7 Years of Surveillance. Pediatr Infect Dis J. 2017 Mar;36(3):256-262. https://doi.org/10.1097/INF.0000000000001414
Castor ML, et al. Antibiotic Resistance Patterns in Invasive Group B Streptococcal Isolates. Infect Dis Obstet Gynecol. 2008;2008:727505. https//:doi.org/10.1155/2008/727505
Teatero S, et al. Serotype Distribution, Population Structure, and Antimicrobial Resistance of Group B Streptococcus Strains Recovered from Colonized Pregnant Women. J Clin Microbiol. 2017 Feb;55(2):412-422. https://doi.org/10.1128/JCM.01615-16
Bulska M, et al. The Placental Transfer of Erythromycin in Human Pregnancies with Group B Streptococcal Infection. Ginekol Pol. 2015 Ene;86(1):33-9. https://doi.org/10.17772/gp/1896
Salkind AR, et al. The Rational Clinical Examination. Is this Patient Allergic to Penicillin? An Evidence-Based Analysis of the Likelihood of Penicillin Allergy.JAMA. 2001 May 16;285(19):2498-505. https://doi.org/10.1001/jama.285.19.2498
Joint Task Force on Practice Parameters; American Academy of Allergy, Asthma and Immunology; American College of Allergy, Asthma and Immunology; Joint Council of Allergy, Asthma and Immunology.Drug allergy: an updated practice parameter.Ann Allergy Asthma Immunol. 2010 Oct;105(4):259-273.https://doi.org/10.1016/j.anai.2010.08.002
Macy E, Vyles D. Who needs penicillin allergy testing? Ann Allergy Asthma Immunol. 2018 Nov;121(5):523-529. https://doi.org/10.1016/j.anai.2018.07.041
Melin P, Efstratiou A. Group B streptococcal epidemiology and vaccine needs in developed countries.Vaccine.2013; 28; 31 Suppl 4:D31-42. Disponible en:http://goo.gl/hGvBTZ
Stylianopoulos A, et al. Is Penicillin and/or Erythromycin Resistance Present in Clinical Isolates of Group B Streptococcus in our Community? Aust N Z J Obstet Gynaecol. 2002 Nov;42(5):543-4. https://doi.org/10.1111/j.0004-8666.2002.00543.x
Martín V, et al. Rectal and Vaginal Eradication of Streptococcus agalactiae (GBS) in Pregnant Women by Using Lactobacillus salivarius CECT 9145. A Target Target-specific Probiotic Strain. Nutrients. 2019;11(4):810.https://doi.org/10.3390/nu11040810
Fernandez M, et al. Antimicrobial Susceptibilities of Group B Streptococci Isolated between 1992 and 1996 from Patients with Bacteremia or Meningitis. Antimicrob Agents Chemother. 1998 Jun;42(6):1517-9.https://doi.org/10.1128/AAC.42.6.1517
Pearlman MD, et al. Frequent Resistance of Clinical Group B Streptococci Isolates to Clindamycin and Erythromycin. Obstet Gynecol. 1998 Ago;92(2):258-61. https://doi.org/10.1016/s0029-7844(98)00155-0
González-Lama Z, et al. Sensibilidad de estreptococo beta hemolítico grupos A, B y C a antibióticos. Rev Esp Quimioter. 1999;12(3):215-19.
Takahashi T, et al. Clonal Distribution of Clindamycin-Resistant Erythromycin-Susceptible (CRES) Streptococcus agalactiae in Korea Based on Whole Genome Sequences. Ann Lab Med. 2020;40(5):370-381.https://doi.org/10.3343/alm.2020.40.5.37
Betriu C, et al. Erythromycin and Clindamycin Resistance and Telithromycin Susceptibility in Streptococcus agalactiae. Antimicrob Agents Chemother. 2003;47(3):1112-14. https://doi.org/10.1128/AAC.47.3.1112-1114.2003
Schrag S, et al. Prevention of Perinatal Group B Streptococcal Disease Revised Guidelines from CDC.MMWR Recomm Rep 2002 Ago 16;51(RR-11):1-22.PMID: 12211284
Sociedad Española de Ginecología y Obstetricia (SEGO). Sociedad Española de Neonatología (SEN).Sociedad Española de Enfermedades Infecciosas y Microbiología Clínica (SEIMC). Sociedad Española de Quimioterapia (SEQ). Sociedad Española de Medicina Familiar y Comunitaria (SEMFYC). Prevención de la infección perinatal por estreptococo del grupo B. Recomendaciones españolas revisadas. Enferm Infecc Microbiol Clin 2003;21:417-23.
Lin FYC, et al. Antibiotic Susceptibility Profiles for Group B Streptococci Isolated from Neonates, 1995-1998. Clin Infect Dis 2000;31(1):76-9. https://doi.org/10.1086/313936
Fitoussi F, et al. Mechanisms of Macrolide Resistance in clinical Group B Streptococci Isolated in France. Antimicrob Agents Chemother. 2001 Jun;45(6):1889-91. https://doi.org/10.1128/AAC.45.6.1889-1891.2001
Ko WC, et al. Serotyping and Antimicrobial Susceptibility of Group B Streptococcus over an Eight Years Period in Southern Taiwan. Eur J Clin Microbiol Infect Dis. 2001 May;20(5):334-9. https://doi.org/10.1007/s100960100505
Morales WJ, et al. Change in Antibiotic Resistance of Group B Streptococcus: Impact on Intrapartum Management.Am J Obstet Gynecol. 1999 Ago;181(2):310-4. https://doi.org/10.1016/s0002-9378(99)70553-3
Murdoch DR, Reller B. Antimicrobial Susceptibilities of group B Streptococci Isolated from Patients with Invasive Disease: 10 years Perspective. Antimicrob Agents Chemother. 2001 Dic;45(12):3623-4. https://doi.org/10.1128/AAC.45.12.3623-3624.2001
Johnson, M.Clindamicina: una descripción general. UpToDate; 2022.Disponible en: https://www.uptodate.com/contents/clindamycin-an-overview?-search=streptococcus%20agalactiae&source=search_result&selectedTitle=22~150&usage_type=default&-display_rank=22
Ardanuy C, et al. Detección fenotípica de mecanismos de resistencia en grampositivos. Enferm Infecc Microbiol Clin. 2012 Jun-Jul;30(6):325-32. https://doi.org/10.1016/j.eimc.2011.09.009
Díaz M, et al. Infección por estreptococo del grupo B en niños después del período neonatal. Rev Cubana Pediatr 2006 Dic;78(4). Disponible en: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S0034-75312006000400001&lng=es
Crespo MP, et al. Importancia clínica del Streptococcus agalactiae como causante de infección.Colomb Med 1996;27(2):53-8. Disponible en: https://colombiamedica.univalle.edu.co/index.php/comedica/article/view/19
Campo CH, et al. Prevalencia de colonización vaginorrectal por Streptococcus agalactiae y su perfil de sensibilidad en mujeres embarazadas atendidas en un hospital de tercer nivel. Biomédica. 2019 Dic;39(4):689-698.http://dx.doi.org/10.7705/biomedica.4514
Kimura K. Series of Studies Concerning Group B Streptococci with Reduced Penicillin Susceptibility (PRGBS). Nihon Saikingaku Zasshi. 2014;69:547-55.https://doi.org/10.3412/jsb.69.547
Copyright (c) 2023 Revista Med
Este trabalho está licenciado sob uma licença Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.