Más allá del molesto ronquido: síndrome de apnea obstructiva del sueño y su peligrosa asociación con el síndrome metabólico

  • James M. Yurgaky S. Universidad Militar Nueva Granada
  • Alirio Bastidas Hospital Militar
  • Jhon A. Universidad Militar Nueva Granada
  • Jaime A. Montaña Universidad Militar Nueva Granada
  • Ana María Arredondo G. Universidad Militar Nueva Granada
Palabras clave: apnea del sueño obstructiva, Síndrome X metabólico, hipertensión

Resumen

El síndrome de apnea hipoapnea obstructiva del sueño (SAHOS) es una enfermedad frecuente que afecta alrededor del 5 % de la población general y a casi la mitad de los pacientes obesos. La asociación de SAHOS con obesidad ha sido bien establecida desde que fue descrito por primera vez; durante los últimos años ha sido creciente la producción literaria que asocia la hipoxemia con un incremento de la enfermedad cardiovascular y metabólica, las cuales finalmente originan un mayor riesgo cardiovascular en los pacientes afectados no necesariamente obesos. Debido a la presencia de hipoxemia secundaria a la obstrucción mecánica del flujo aéreo que se encuentra en los pacientes afectados por el síndrome de apnea hipoapnea obstructiva del sueño, se desencadenan eventos fisiopatogénicos tales como la liberación de radicales libres, la disminución de la expresión de algunas enzimas importantes para el clivaje del colesterol y la producción de óxido nítrico y el aumento en la producción de mediadores inflamatorios que generan disrupción de vías metabólicas y endocrinológicas, lo cual ocasiona un incremento en el riesgo de sufrir diabetes mellitus, resistencia a la insulina, hipertensión arterial, obesidad y dislipidemia aterogénica.

Biografía del autor/a

James M. Yurgaky S., Universidad Militar Nueva Granada
Residente del programa de Endocrinología, Facultad de Medicina, Universidad Militar Nueva Granada, Bogotá. Colombia.
Alirio Bastidas, Hospital Militar
Neumólogo y Epidemiólogo Hospital Militar de Bogotá, Colombia
Jhon A., Universidad Militar Nueva Granada

Residente del programa de Medicina Interna, Facultad de Medicina, Universidad Militar Nueva Granada, Bogotá, Colombia

Jaime A. Montaña, Universidad Militar Nueva Granada

Residente del programa de Medicina Interna, Facultad de Medicina, Universidad Militar Nueva Granada, Bogotá, Colombia

Ana María Arredondo G., Universidad Militar Nueva Granada

Residente del programa de Medicina Interna, Facultad de Medicina, Universidad Militar Nueva Granada, Bogotá, Colombia

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Biografía del autor/a

James M. Yurgaky S., Universidad Militar Nueva Granada
Residente del programa de Endocrinología, Facultad de Medicina, Universidad Militar Nueva Granada, Bogotá. Colombia.
Alirio Bastidas, Hospital Militar
Neumólogo y Epidemiólogo Hospital Militar de Bogotá, Colombia
Jhon A., Universidad Militar Nueva Granada

Residente del programa de Medicina Interna, Facultad de Medicina, Universidad Militar Nueva Granada, Bogotá, Colombia

Jaime A. Montaña, Universidad Militar Nueva Granada

Residente del programa de Medicina Interna, Facultad de Medicina, Universidad Militar Nueva Granada, Bogotá, Colombia

Ana María Arredondo G., Universidad Militar Nueva Granada

Residente del programa de Medicina Interna, Facultad de Medicina, Universidad Militar Nueva Granada, Bogotá, Colombia

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Cómo citar
Yurgaky S., J. M., Bastidas, A., A., J., Montaña, J. A., & Arredondo G., A. M. (2011). Más allá del molesto ronquido: síndrome de apnea obstructiva del sueño y su peligrosa asociación con el síndrome metabólico. Revista Med, 19(1), 37-44. https://doi.org/10.18359/rmed.1275
Publicado
2011-06-30
Sección
Artículos