Género Aspergillus: fuente potencial de péptidos bioactivos

Palabras clave: actividades bioquímicas, Aspergillus, metabolismo, péptidos

Resumen

Los hongos del género Aspergillus son mohos filamentosos de distribución cosmopolita que participan en diferentes procesos en la naturaleza. Se ha reportado el uso de este género en fermentaciones con diversos sustratos para producir péptidos bioactivos u obtener otro tipo de metabolitos benéficos. En la salud humana, los péptidos son utilizados por las diferentes actividades biológicas que estos exhiben y su fácil absorción intestinal. Por lo anterior, se realizó una revisión bibliográfica siguiendo el método Prisma, utilizando la ecuación de búsqueda “bioactive peptides” AND “Aspergillus” en las bases de datos Scopus, Web of Science y Lens, con el fin de consolidar la información relacionada con el género y su producción de péptidos. La búsqueda arrojó 113 artículos, de los cuales se seleccionaron once, que indicaban que tan solo cinco especies del género Aspergillus han sido analizadas con respecto a sus péptidos bioactivos, obtenidos en fermentaciones. Aspergillus niger y Aspergillus oryzae son los más estudiados. Se concluye, que el género Aspergillus es una fuente potencial de péptidos bioactivos. Por otro lado, el artículo es uno de los primeros en sintetizar y analizar la información sobre péptidos bioactivos derivados de fermentaciones con este hongo, por lo que abre perspectivas para llevar a cabo investigaciones similares y acompañar los avances en esta área.

Biografía del autor/a

Marcela Patricia Gómez Rojas, Universidad Tecnológica de Pereira, Risaralda, Colombia

Química Industrial, Tecnóloga Química. Grupo de Biotecnología-Productos Naturales, Escuela de Tecno- logía Química, Facultad de Tecnología, Universidad Tecnológica de Pereira, Pereira, Risaralda, Colombia. Correo electrónico: mpgomez@utp.edu.co ORCID: https://orcid.org/0000-0003-2299-9823

Jorge William Arboleda Valencia, Universidad de Antioquia, Medellín, Colombia

Ph. D. Ciencias Básicas, Ingeniero Agrónomo, Profesor Asociado, Universidad de Antioquia, Facultad de Ciencias Exactas y Naturales, Instituto de Biología, Medellín, Colombia.
Correo electrónico: jwilliam.arboleda@udea.edu.co ORCID: https://orcid.org/0000-0001-6165-978X

Oscar Marino Mosquera Martínez, Universidad Tecnológica de Pereira, Risaralda, Colombia

M. Sc. Agroquímica, Químico. Grupo de Biotecnología-Productos Naturales, Escuela de Tecnología Química, Facultad de Tecnología, Universidad Tecnológica de Pereira, Pereira, Risaralda, Colombia.
Correo electrónico: omosquer@utp.edu.co ORCID: https://orcid.org/0000-0003-2998-0842

Descargas

La descarga de datos todavía no está disponible.

Biografía del autor/a

Marcela Patricia Gómez Rojas, Universidad Tecnológica de Pereira, Risaralda, Colombia

Química Industrial, Tecnóloga Química. Grupo de Biotecnología-Productos Naturales, Escuela de Tecno- logía Química, Facultad de Tecnología, Universidad Tecnológica de Pereira, Pereira, Risaralda, Colombia. Correo electrónico: mpgomez@utp.edu.co ORCID: https://orcid.org/0000-0003-2299-9823

Jorge William Arboleda Valencia, Universidad de Antioquia, Medellín, Colombia

Ph. D. Ciencias Básicas, Ingeniero Agrónomo, Profesor Asociado, Universidad de Antioquia, Facultad de Ciencias Exactas y Naturales, Instituto de Biología, Medellín, Colombia.
Correo electrónico: jwilliam.arboleda@udea.edu.co ORCID: https://orcid.org/0000-0001-6165-978X

Oscar Marino Mosquera Martínez, Universidad Tecnológica de Pereira, Risaralda, Colombia

M. Sc. Agroquímica, Químico. Grupo de Biotecnología-Productos Naturales, Escuela de Tecnología Química, Facultad de Tecnología, Universidad Tecnológica de Pereira, Pereira, Risaralda, Colombia.
Correo electrónico: omosquer@utp.edu.co ORCID: https://orcid.org/0000-0003-2998-0842

Referencias Bibliográficas

F. Lamoth, P. R. Juvvadi y W. J. Steinbach, "Editorial. Advances in Aspergillus fumigatus pathobiology", Frontiers in Microbiology, vol. 7, 2016. DOI: https://doi.org/10.3389/fmicb.2016.00043

A. M. Abdel-Azeem, M. A. Abdel-Azeem, S. Y. Abdul-Hadi y A. G. Darwish, "Aspergillus. Biodiversity, ecological significances, and industrial applications". En A. N. Yadav et al. (Eds.), Recent advancement in white biotechnology through fungi, Springer, 2019, pp. 121-179. DOI: https://doi.org/10.1007/978-3-030-10480-1_4

S. L. Bahna, R. D'Mello y S. Kilaikode, "Allergic bronchopulmonary aspergillosis", Int. J. Immunorehabil., vol. 21, n.° 1, pp. 3-7, 2019. DOI: https://doi.org/10.22363/2313-0245-2019-23-1-62-69

L. Alcalá, P. Muñoz, T. Peláez y E. Bouza, "Aspergillus y aspergilosis", 2018. https://www.seimc.org/contenidos/ccs/revisionestematicas/micologia/asperguillus.pdf

R. J. Lee et al., "Fungal aflatoxins reduce respiratory mucosal ciliary function", Sci. Rep., vol. 6, n.° 1, pp. 1-13, 2016. DOI: https://doi.org/10.1038/srep33221

P. L. Show, K. O. Oladele, Q. Y. Siew, F. A. Aziz Zakry, J. C.-W. Lan y T. C. Ling, "Overview of citric acid production from Aspergillus niger", Front. Life Sci., vol. 8, n.° 3, pp. 271-283, 2015. DOI: https://doi.org/10.1080/21553769.2015.1033653

P. Hahn, A. Kasprzycka y W. Szeja, "Synthesis of 2-deoxygalactopyranoside derivatives of benzyl alcohols with β-galactosidase from Aspergillus oryzae", Biocatal. Biotransformation, vol. 32, n.° 5-6, pp. 290-294, 2014. DOI: https://doi.org/10.3109/10242422.2014.975216

K. M. Kim, J. Lim, J. J. Lee, B. S. Hurh y I. Lee, "Characterization of Aspergillus sojae isolated from meju, korean traditional fermented soybean brick", J. Microbiol. Biotechnol., vol. 27, n.° 2, pp. 251-261, 2017. DOI: https://doi.org/10.4014/jmb.1610.10013

M. A. Lima, M. D. de Oliveira, A. T. Pimenta y P. K. Uchôa, "Aspergillus Niger. A hundred years of contribution to the natural products chemistry", Journal of the Brazilian Chemical Society, vol. 30, n.° 10. pp. 2029-2059, 2019. DOI:

https://doi.org/10.21577/0103-5053.20190080

K. F. Nielsen, J. M. Mogensen, M. Johansen, T. O. Larsen y J. C. Frisvad, "Review of secondary metabolites and mycotoxins from the Aspergillus niger group", Analytical and Bioanalytical Chemistry, vol. 395, n.° 5. pp. 1225-1242, 2009. DOI: https://doi.org/10.1007/s00216-009-3081-5

B. Dhandapani, S. Mahadevan y S. Muthiah, "Conversion of agro by-products to an alkaline protease by Aspergillus tamarii and the usefulness of its metabolic heat for better process understanding", Waste and Biomass Valorization, vol. 11, n.° 6, pp. 2623-2629, 2020. DOI: https://doi.org/10.1007/s12649-019-00608-x

N. Gonsales, A. C. Rodrigues, V. N. Hirano, A. Rodrigues y H. Cabral, "Amino acid supplementation improves the production of extracellular peptidases by Aspergillus Section Flavi and their ionic immobilization Benevides Costa Pessela 3", Brazilian Arch. Biol. Technol., vol. 63, p. 2020, 2020. DOI: https://doi.org/10.1590/1678-4324-2020190127

A. Balakrishnan et al., "Evaluation of in vitro activities of extracellular enzymes from Aspergillus species isolated from corneal ulcer/keratitis", Saudi J. Biol. Sci., vol. 27, n.° 2, pp. 701-705, 2020. DOI: https://doi.org/10.1016/j.sjbs.2019.11.023

E. A. Beltagy, M. Rawway, U. M. Abdul-Raouf, M. A. Elshenawy y M. S. Kelany, "Purification and characterization of theromohalophilic chitinase producing by halophilic Aspergillus flavus isolated from Suez Gulf", Egypt. J. Aquat. Res., vol. 44, n.° 3, pp. 227-232, 2018. DOI: https://doi.org/10.1016/j.ejar.2018.08.002

A. O. Adejuwon, V. A. Tsygankova y O. Alonge, "Effect of cultivation conditions on activity of α-amylase from a tropical strain Aspergillus flavus link", J. Microbiol. Biotechnol. Food Sci., vol. 7, n.° 6, pp. 571-575, 2018. DOI:

https://doi.org/10.15414/jmbfs.2018.7.6.571-575

G. Anand, S. Yadav y D. Yadav, "Purification and biochemical characterization of an exo-polygalacturonase from Aspergillus flavus MTCC 7589", Biocatal. Agric. Biotechnol., vol. 10, pp. 264-269, 2017. DOI:

https://doi.org/10.1016/j.bcab.2017.03.018

J. Tang et al., "Improved protease activity of pixian broad bean paste with cocultivation of Aspergillus oryzae QM-6 and Aspergillus niger QH-3", Electron. J. Biotechnol., vol. 44, pp. 33-40, 2020. DOI: https://doi.org/10.1016/j.ejbt.2020.01.001

K. Ichikawa et al., "Efficient production of recombinant tannase in Aspergillus oryzae using an improved glucoamylase gene promoter", J. Biosci. Bioeng., vol. 129, n.° 2, pp. 150-154, 2020. DOI: https://doi.org/10.1016/j.jbiosc.2019.08.002

K. Jatuwong, N. Suwannarach, J. Kumla, W. Penkhrue, P. Kakumyan y S. Lumyong, "Bioprocess for production, characteristics y biotechnological applications of fungal phytases", Frontiers in Microbiology, vol. 11, pp. 1-18, 2020. DOI: https://doi.org/10.3389/fmicb.2020.00188

A. Ahmed, R. Badar y N. Khalique, "Screening and optimization of submerged fermentation of lipolytic Aspergillus oryzae", BioResources, vol. 14, n.° 4, pp. 7664-7674, 2019. DOI: https://www.doi.org/10.15376/biores.14.4.7664-7674

J. S. Cunha, C. A. Ottoni, S. A. Morales, E. S. Silva, A. E. Maiorano y R. F. Perna, "Synthesis and characterization of fructosyltransferase from Aspergillus oryzae IPT-301 for high fructooligosaccharides production", Brazilian J. Chem. Eng., vol. 36, n.° 2, pp. 657-668, 2019. DOI: https://doi.org/10.1590/0104-6632.20190362s20180572

N. Bhardwaj, B. Kumar, K. Agarwal, V. Chaturvedi y P. Verma, "Purification and characterization of a thermo-acid/alkali stable xylanases from Aspergillus oryzae LC1 and its application in Xylo-oligosaccharides production from lignocellulosic agricultural wastes", Int. J. Biol. Macromol., vol. 122, pp. 1191-1202, 2019. DOI: https://doi.org/10.1016/j.ijbiomac.2018.09.070

J. Škerlová et al., "Crystal structure of native β-N-acetylhexosaminidase isolated from Aspergillus oryzae sheds light onto its substrate specificity, high stability y regulation by propeptide", FEBS J., vol. 285, n.° 3, pp. 580-598, 2018. DOI: https://doi.org/10.1111/febs.14360

Y. Zhu, H. Jia, M. Xi, J. Li, L. Yang y X. Li, "Characterization of a naringinase from Aspergillus oryzae 11250 and its application in the debitterization of orange juice", Process Biochem., vol. 62, pp. 114-121, 2017. DOI: https://doi.org/10.1016/j.procbio.2017.07.012

K. D. Wang, K. H. Wang, N. Di Zhou y Y. P. Tian, "Secretory expression, purification, characterization y application of an Aspergillus oryzae prolyl aminopeptidase in bacillus subtilis", Appl. Biochem. Biotechnol., vol. 181, n.° 4, pp. 1611-1623, 2017. DOI: https://doi.org/10.1007/s12010-016-2305-3

P. R. Heinen et al., "GH11 xylanase from Aspergillus tamarii Kita. Purification by one-step chromatography and xylooligosaccharides hydrolysis monitored in real-time by mass spectrometry", Int. J. Biol. Macromol., vol. 108, pp. 291-299, 2018. DOI: https://doi.org/10.1016/j.ijbiomac.2017.11.150

A. R. de Sena et al., "Kinetic, thermodynamic parameters and in vitro digestion of tannase from Aspergillus tamarii URM 7115", Chem. Eng. Commun., vol. 205, n.° 10, pp. 1415-1431, 2018. DOI: https://doi.org/10.1080/00986445.2018.1452201

E. Liu, M. Li, A. Abdella y M. R. Wilkins, "Development of a cost-effective medium for submerged production of fungal aryl alcohol oxidase using a genetically modified Aspergillus nidulans strain", Bioresour. Technol., vol. 305, 2020. DOI: https://doi.org/10.1016/j.biortech.2020.123038

Y. Khambhaty, R. Akshaya, C. Rama Suganya, K. J. Sreeram y J. Raghava Rao, "A logical and sustainable approach towards bamboo pulp bleaching using xylanase from Aspergillus nidulans", Int. J. Biol. Macromol., vol. 118, pp. 452-459, 2018. DOI: https://doi.org/10.1016/j.ijbiomac.2018.06.100

B. R. Shruthi, R. N. Achur y T. Nayaka, "Optimized solid-state fermentation medium enhances the multienzymes production from Penicillium citrinum and Aspergillus clavatus", Curr. Microbiol., vol. 1, p. 3, 2020. DOI: https://doi.org/10.1007/s00284-020-02036-w

D. N. Putri, A. Khootama, M. S. Perdani, T. S. Utami y H. Hermansyah, "Optimization of Aspergillus niger lipase production by solid state fermentation of agroindustrial waste", Energy Reports, vol. 6, pp. 331-335, 2020. DOI: https://doi.org/10.1016/j.egyr.2019.08.064

S. Xing, R. Zhu, C. Li, L. He, X. Zeng y Q. Zhang, "Gene cloning, expression, purification and characterization of a sn-1,3 extracellular lipase from Aspergillus niger GZUF36", J. Food Sci. Technol., vol. 57, n.° 7, pp. 2669-2680, 2020. DOI: https://doi.org/10.1007/s13197-020-04303-x

A. Kaur, V. Rishi, S. Kumar Soni y P. Rishi, "A novel multi-enzyme preparation produced from Aspergillus niger using biodegradable waste: a possible option to combat heterogeneous biofilms", AMB Express, vol. 10, n.° 36, 2020. DOI: https://doi.org/10.1186/s13568-020-00970-3

M. Zhao, X. Y. Wang, S. H. Xu, G. Q. Yuan, X. J. Shi y Z. H. Liang, "Degradation of ochratoxin A by supernatant and ochratoxinase of Aspergillus niger W-35 isolated from cereals ", World Mycotoxin J., vol. 13, n.° 2, pp. 287-298, 2020. DOI: https://doi.org/10.3920/WMJ2019.2446

M. Germec y I. Turhan, "Evaluation of carbon sources for the production of inulinase by Aspergillus niger A42 and its characterization", Bioprocess Biosyst. Eng., vol. 42, n.° 12, pp. 1993-2005, 2019. DOI: https://doi.org/10.1007/s00449-019-02192-9

R. D. Martarello et al., "Optimization and partial purification of beta-galactosidase production by Aspergillus niger isolated from Brazilian soils using soybean residue", AMB Express, vol. 9, n.° 1, 2019. DOI: https://doi.org/10.1186/s13568-019-0805-6

X. Chen, B. Wang y L. Pan, "Heterologous expression and characterization of Penicillium citrinum nuclease P1 in Aspergillus niger and its application in the production of nucleotides", Protein Expr. Purif., vol. 156, pp. 36-43, 2019. DOI: https://doi.org/10.1016/j.pep.2018.12.004

D. E. Nayab, M. Z. Haider, S. Shahid, y T. Iftikhar, "In silico phylogenetic analysis of fungal lipase genes and harnessing the inherent potential of Aspergillus niger IBP2013 for extracellular triglycerol acyl-hydrolase production under solid state fermentation", Pakistan Journal of Botany, vol. 50, n.° 5, pp. 2019-2029, 2018.

M. R. Javed, M. H. Rashid, M. Riaz, H. Nadeem, M. Qasim y N. Ashiq, "Physiochemical and thermodynamic characterization of highly active mutated Aspergillus niger β-glucosidase for lignocellulose hydrolysis", Protein Pept. Lett., vol. 25, 2018. DOI: https://doi.org/10.2174/0929866525666180130161504

U. S. P. Uday et al., "Isolation, screening and characterization of a novel extracellular xylanase from Aspergillus niger (KP874102.1) and its application in orange peel hydrolysis", Int. J. Biol. Macromol., vol. 105, pp. 401-409, 2017. DOI: https://doi.org/10.1016/j.ijbiomac.2017.07.066

P. Agarwal, J. Singh y R. P. Singh, "Molecular cloning and characteristic features of a novel extracellular tyrosinase from Aspergillus niger PA2", Appl. Biochem. Biotechnol., vol. 182, n.° 1, 2017. DOI: https://doi.org/10.1007/s12010-016-2306-2

M. M. El-Metwally y Y. M. M. Mohammed, "Production and application of thermostable glucoamylase from thermotolerant Aspergillus fumigatus via semisolid state fermentation", Egypt. J. Bot., vol. 59, n.° 3, pp. 811-826, 2019.

R. M. F. Cavalcanti, J. A. Jorge y L. H. Guimarães, "Characterization of Aspergillus fumigatus CAS-21 tannase with potential for propyl gallate synthesis and treatment of tannery effluent from leather industry", 3 Biotech, vol. 8, n.° 6, 2018. DOI: https://doi.org/10.1007/s13205-018-1294-z

C. Lin, Z. Shen y W. Qin, "Characterization of xylanase and cellulase produced by a newly isolated Aspergillus fumigatus N2 and its efficient saccharification of barley straw", Appl. Biochem. Biotechnol., vol. 182, n.° 2, pp. 559-569, 2017. DOI: https://doi.org/10.1007/s12010-016-2344-9

C. Elena, P. Ravasi, M. E. Castelli, S. Peirú y H. G. Menzella, "Expression of codon optimized genes in microbial systems. Current industrial applications and perspectives", Frontiers in Microbiology, vol. 5, pp. 1-21, 2014. DOI: https://doi.org/10.3389/fmicb.2014.00021

L. R. Torres, M. T. Álvarez, G. Mendoza y G. Aguilar, "Analysis of polysaccharide hydrolases secreted by Aspergillus flavipes FP-500 on corn cobs and wheat bran as complex carbon sources", Prep. Biochem. Biotechnol., vol. 50, n.° 4, pp. 390-400, 2020. DOI: https://doi.org/10.1080/10826068.2019.1700518

V. E. Wolf-Márquez et al., "Scaling-up and ionic liquid-based extraction of pectinases from Aspergillus flavipes cultures", Bioresour. Technol., vol. 225, pp. 326-335, 2017. DOI: https://doi.org/10.1016/j.biortech.2016.11.067

F. M. Aracri, R. M. F. Cavalcanti y L. H. S. Guimarães, "Extracellular tannase from Aspergillus ochraceus. Influence of the culture conditions on biofilm formation, enzyme production y application", J. Microbiol. Biotechnol., vol. 29, n.° 11, pp. 1749-1759, 2019. DOI: https://doi.org/10.4014/jmb.1903.03060

L. M. Tódero, C. G. Rechia y L. H. Guimarães, "Production of short-chain fructooligosaccharides (scFOS) using extracellular β-D-fructofuranosidase produced by Aspergillus thermomutatus", J. Food Biochem., vol. 43, n.° 8, 2019. DOI: https://doi.org/10.1111/jfbc.12937

S. Netsopa, S. Niamsanit, T. Araki, M. B. Kongkeitkajorn y N. Milintawisamai, "Purification and characterization including dextran hydrolysis of dextranase from Aspergillus allahabadii X26", Sugar Tech, vol. 21, n.° 2, pp. 329-340, 2019. DOI: https://doi.org/10.1007/s12355-018-0652-9

D. Stack, C. Neville y S. Doyle, "Nonribosomal peptide synthesis in Aspergillus fumigatus and other fungi", Microbiology, vol. 153, n.° 5. Microbiology Society, pp. 1297-1306, 2007. DOI: https://doi.org/10.1099/mic.0.2006/006908-0

J. Soltani, "Secondary metabolite diversity of the genus Aspergillus: Recent Advances". En V. K. Gupta (Ed) New and future developments in microbial biotechnology and bioengineering: Aspergillus system properties and applications, V. K. Gupta, Ed. Amsterdam: Elsevier, 2016, pp. 275-292. DOI: https://doi.org/10.1016/B978-0-444-63505-1.00035-X

N. Nagano et al., "Class of cyclic ribosomal peptide synthetic genes in filamentous fungi", Fungal Genet. Biol., vol. 86, pp. 58-70, 2016. DOI: https://doi.org/10.1016/j.fgb.2015.12.010

Y. Zhang, M. Chen, S. D. Bruner y Y. Ding, "Heterologous production of microbial ribosomally synthesized and post-translationally modified peptides", Frontiers in Microbiology, vol. 9, p. 1801, 2018. DOI: https://doi.org/10.3389/fmicb.2018.01801

Y. Le Govic, N. Papon, S. Le Gal, J.-P. Bouchara y P. Vandeputte, "Non-ribosomal peptide synthetase gene clusters in the human pathogenic fungus Scedosporium apiospermum", Front. Microbiol., vol. 10, p. 2062, 2019. DOI: https://doi.org/10.3389/fmicb.2019.02062

A. Miyanaga, F. Kudo y T. Eguchi, "Protein-protein interactions in polyketide synthase-nonribosomal peptide synthetase hybrid assembly lines", Natural Product Reports, vol. 35, n.° 11, pp. 1185-1209, 2018. DOI: https://doi.org/10.1039/C8NP00022K

J. A. Cortés y J. A. Russi N, "Equinocandinas", Rev. Chil. infectología, vol. 28, n.° 6, pp. 529-536, Dec. 2011. DOI: https://doi.org/10.4067/S0716-10182011000700004

A. P. Majumdar, "Echinocandins in antifungal pharmacotherapy", J. Pharm. Pharmacol., vol. 69, n.° 12, p. 12, 2017. DOI: https://doi.org/10.1111/jphp.12780

J. A. Cortés y J. A. Russi, "Equinocandinas", Revista Chilena de Infectologia, vol. 28, n.° 6, pp. 529-536, 2011. DOI: https://doi.org/10.4067/S0716-10182011000700004

M. A. Lima, M. D. de Oliveira, A. T. Pimenta y P. K. Uchôa, "Aspergillus niger. A hundred years of contribution to the natural products chemistry", Journal of the Brazilian Chemical Society, vol. 30, n.° 10, pp. 2029-2059, 2019. DOI: https://doi.org/10.21577/0103-5053.20190080

Y. Zhuang et al., "Cyclopeptides and polyketides from coral-associated fungus, Aspergillus versicolor LCJ-5-4", Tetrahedron, vol. 67, n.° 37, pp. 7085-7089, 2011. DOI: https://doi.org/10.1016/j.tet.2011.07.003

X. Bin Li, Y. L. Li, J. C. Zhou, H. Q. Yuan, X. N. Wang y H. X. Lou, "A new diketopiperazine heterodimer from an endophytic fungus Aspergillus Niger", J. Asian Nat. Prod. Res., vol. 17, n.° 2, pp. 182-187, 2015. DOI: https://doi.org/10.1080/10286020.2014.959939

H. Ma et al., "A new diketopiperazine from an endophytic fungus Aspergillus aculeatus F027", Nat. Prod. Res., 2019. DOI: https://doi.org/10.1080/14786419.2019.1677652

X. Liang, X. Zhang, X. Lu, Z. Zheng, X. Ma y S. Qi, "Diketopiperazine-type alkaloids from a deep-sea-derived Aspergillus puniceus fungus and their effects on liver X receptor α", J. Nat. Prod., vol. 82, n.° 6, pp. 1558-1564, 2019. DOI: https://doi.org/10.1021/acs.jnatprod.9b00055

X. Luo et al., "Structurally diverse diketopiperazine alkaloids from the marine-derived fungus: Aspergillus versicolor SCSIO 41016", Org. Chem. Front., vol. 6, n.° 6, pp. 736-740, 2019. DOI: https://doi.org/10.1039/C8QO01147H

H. Wen et al., "Three new indole diketopiperazine alkaloids from Aspergillus ochraceus", Chem. Biodivers., vol. 15, n.° 4, 2018. DOI: https://doi.org/10.1002/cbdv.201700550

A. Kaur et al., "New diketopiperazine dimer from a filamentous fungal isolate of Aspergillus sydowii", Magn. Reson. Chem., vol. 53, n.° 8, pp. 616-619, 2015. DOI: https://doi.org/10.1002/mrc.4254

S. Cai et al., "Okaramines S-U, three new indole diketopiperazine alkaloids from Aspergillus taichungensis ZHN-7-07", Tetrahedron, vol. 71, n.° 22, pp. 3715-3719, 2015. DOI: https://doi.org/10.1016/j.tet.2014.09.019

S. Cai et al., "Erratum. Aspergilazine A, a diketopiperazine dimer with a Rare N-1 to C-6 linkage, from a marine-derived fungus Aspergillus taichungensis (Tetrahedron Letters (2012) 53 (2615-2617))", Tetrahedron Letters, vol. 55, n.° 39, p. 5404, 2014. DOI: https://doi.org/10.1016/j.tetlet.2014.07.001

M. Shaaban, M. M. El-Metwally y H. Nasr, "A new diketopiperazine alkaloid from Aspergillus oryzae", Nat. Prod. Res., vol. 28, n.° 2, pp. 86-94, 2014. DOI: https://doi.org/10.1080/14786419.2013.841687

H. Drechsel y G. Jung, "Peptide siderophores", Journal of Peptide Science, vol. 4, n.° 3, pp. 147-181, 1998. DOI: https://doi.org/10.1002/(SICI)1099-1387(199805)4:3<147::AID-PSC136>3.0.CO;2-C

A. H. Hissen, A. N. Wan, M. L. Warwas, L. J. Pinto y M. M. Moore, "The Aspergillus fumigatus siderophore biosynthetic gene sidA, encoding L-ornithine N5-oxygenase, is required for virulence", Infect. Immun., vol. 73, n.° 9, pp. 5493-5503, 2005. DOI: https://doi.org/10.1128/IAI.73.9.5493-5503.2005

A. Beneduzi, A. Ambrosini y L. M. Passaglia, "Plant growth-promoting rhizobacteria (PGPR): Their potential as antagonists and biocontrol agents", 2012. https://lume.ufrgs.br/handle/10183/87984?locale-attribute=es

S. S. ALI and V. NN, "Evaluation of siderophore produced by different clinical isolate pseudomonas aeruginosa", Int. J. Microbiol. Res., vol. 3, n.° 3, pp. 131-135, 2011. DOI: https://doi.org/10.9735/0975-5276.3.3.131-135

N. A. Furtado, M. T. Pupo, I. Carvalho, V. L. Campo, M. C. Duarte y J. K. Bastos, "Diketopiperazines produced by an Aspergillus fumigatus Brazilian strain", J. Braz. Chem. Soc., vol. 16, n.° 6B, pp. 1448-1453, 2005. DOI: https://doi.org/10.1590/S0103-50532005000800026

Y. Ding, X. Zhu, L. Hao, M. Zhao, Q. Hua y F. An, "Bioactive indolyl diketopiperazines from the marine derived endophytic Aspergillus versicolor DY180635", Mar. Drugs, vol. 18, n.° 7, 2020. DOI: https://doi.org/10.3390/md18070338

M. Rethlefsen et al., "PRISMA-S: An Extension to the PRISMA Statement for Reporting Literature Searches in Systematic Reviews". OSF Preprints, 20, 2019. DOI: https://doi.org/10.31219/osf.io/sfc38

L. Pastrana, "Fundamentos de la fermentación en estado sólido y aplicación a la industria alimentaria", Cienc. y Tecnol. Aliment., vol. 1, n.° 3, pp. 4-12, 1996. DOI: https://doi.org/10.1080/11358129609487556

K. Sato, S. Miyasaka, A. Tsuji y H. Tachi, "Isolation and characterization of peptides with dipeptidyl peptidase IV (DPPIV) inhibitory activity from natto using DPPIV from Aspergillus oryzae", Food Chem., vol. 261, pp. 51-56, 2018. DOI: https://doi.org/10.1016/j.foodchem.2018.04.029

M. R. Zanutto-Elgui et al., "Production of milk peptides with antimicrobial and antioxidant properties through fungal proteases", Food Chem., vol. 278, pp. 823-831, 2019. DOI: https://doi.org/10.1016/j.foodchem.2018.11.119

M. B. O'Keeffe, R. Norris, M. A. Alashi, R. E. Aluko y R. J. FitzGerald, "Peptide identification in a porcine gelatin prolyl endoproteinase hydrolysate with angiotensin converting enzyme (ACE) inhibitory and hypotensive activity", J. Funct. Foods, vol. 34, pp. 77-88, 2017. DOI: https://doi.org/10.1016/j.jff.2017.04.018

A. E. Alves, L. Carvalho, G. Boscariol y R. J. Soares, "Solid-state fermentation as an efficient strategy for the biotransformation of lentils: enhancing their antioxidant and antidiabetic potentials", Bioresour. Bioprocess., vol. 6, n.° 1, 2019. DOI: https://doi.org/10.1186/s40643-019-0273-5

A. Starzyńska, B. Stodolak, A. M. Gómez, B. Mickowska, B. Martín y Ł. Byczyński, "Mould starter selection for extended solid-state fermentation of quinoa", LWT, vol. 99, pp. 231-237, 2019. DOI: https://doi.org/10.1016/j.lwt.2018.09.055

M. B. O'Keeffe and R. J. Fitzgerald, "Identification of short peptide sequences in complex milk protein hydrolysates", Food Chem., vol. 184, pp. 140-146, 2015. DOI: https://doi.org/10.1016/j.foodchem.2015.03.077

R. J. de Castro y H. H. Sato, "A response surface approach on optimization of hydrolysis parameters for the production of egg white protein hydrolysates with antioxidant activities", Biocatal. Agric. Biotechnol., vol. 4, n.° 1, pp. 55-62, 2015. DOI: https://doi.org/10.1016/j.bcab.2014.07.001

Y. Hou, W. Liu, Y. Cheng, J. Zhou, L. Wu y G. Yang, "Production optimization and characterization of immunomodulatory peptides obtained from fermented goat placenta", Food Sci. Technol., vol. 34, n.° 4, pp. 723-729, 2015. DOI: https://doi.org/10.1590/1678-457X.6448

R. Norris, A. Poyarkov, M. B. O'Keeffe y R. J. Fitzgerald, "Characterisation of the hydrolytic specificity of Aspergillus niger derived prolyl endoproteinase on bovine β-casein and determination of ACE inhibitory activity", Food Chem., vol. 156, pp. 29-36, 2014. DOI: https://doi.org/10.1016/j.foodchem.2014.01.056

Y. Wang, F. Li, M. Chen, Z. Li, W. Liu y C. Wang, "Angiotensin I-converting enzyme inhibitory activities of Chinese traditional soy-fermented Douchi and Soypaste. Effects of processing and simulated gastrointestinal digestion", Int. J. Food Prop., vol. 18, n.° 4, pp. 934-944, 2015. DOI: https://doi.org/10.1080/10942912.2014.913180

B. Singh and A. Kaur, "Antidiabetic potential of a peptide isolated from an endophytic Aspergillus awamori", J. Appl. Microbiol., vol. 120, n.° 2, pp. 301-311, 2016. DOI: https://doi.org/10.1111/jam.12998

"Hypertension" World Health Organization (WHO). https://www.who.int/health-topics/hypertension/#tab=tab_1.

Cómo citar
Gómez Rojas, M. P., Arboleda Valencia, J. W., & Mosquera Martínez, O. M. (2021). Género Aspergillus: fuente potencial de péptidos bioactivos. Revista Facultad De Ciencias Básicas, 17(1), 73-89. https://doi.org/10.18359/rfcb.5610
Publicado
2021-11-19
Sección
Artículos
Crossref Cited-by logo