Eritropoyetina: más allá de la proliferación y maduración eritroide

  • Oscar Andrés Peñuela B. Universidad Militar Nueva Granada
  • Lina Andrea Gómez R. Secretaría Distrital de Salud de Bogotá D.C.
Palabras clave: eritropoyetina, eritropoyesis, apoptosis

Resumen

El sistema hematopoyético de los vertebrados requiere de mecanismos que aseguren una continua producción de nuevas células necesarias para reemplazar los elementos maduros de la sangre que tienen una vida limitada. Esta continua producción es realizada por las células madre pluripotenciales, a través de progenitores multipotenciales, una de las cuales es la línea eritroide. La eritropoyetina (EPO), es el factor clave de este proceso al asegurar, como tradicionalmente se ha sabido, la proliferación y diferenciación del componente inmaduro. De otra parte, una creciente evidencia demuestra que la EPO no solamente está relacionada con el mantenimiento de los precursores eritroides, sino también con la viabilidad de los eritrocitos maduros circulantes. Así mismo, se conocen cada vez más funciones no eritropoyéticas de esta fascinante citoquina, abriendo el panorama terapéutico a muchos pacientes que padecen cáncer o sufren las consecuencias de la isquemia tisular. Este artículo es una revisión general de la biología de la EPO, de sus efectos fisiológicos sobre diferentes tejidos y su relación con los fenómenos de muerte celular programada de los eritrocitos maduros.

Biografía del autor/a

Oscar Andrés Peñuela B., Universidad Militar Nueva Granada
Profesor del departamento de Fisiología, Facultad de Medicina, Universidad Militar Nueva Granada, Bogotá D.C.
Lina Andrea Gómez R., Secretaría Distrital de Salud de Bogotá D.C.
Coordinadora del Banco de Tejidos y Células, Hemocentro Distrital. Secretaría Distrital de Salud de Bogotá D.C.

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Biografía del autor/a

Oscar Andrés Peñuela B., Universidad Militar Nueva Granada
Profesor del departamento de Fisiología, Facultad de Medicina, Universidad Militar Nueva Granada, Bogotá D.C.
Lina Andrea Gómez R., Secretaría Distrital de Salud de Bogotá D.C.
Coordinadora del Banco de Tejidos y Células, Hemocentro Distrital. Secretaría Distrital de Salud de Bogotá D.C.

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Cómo citar
Peñuela B., O. A., & Gómez R., L. A. (2010). Eritropoyetina: más allá de la proliferación y maduración eritroide. Revista Med, 18(1), 67-76. https://doi.org/10.18359/rmed.1292
Publicado
2010-06-30
Sección
Artículos