Aplicaciones médicas de las células pluripotentes inducidas paciente-específicas
Resumen
Los recientes avances en la implementación de estrategias de reprogramación genética en células somáticas para la producción de células pluripotentes inducidas (iPS), abren la posibilidad de generar células pluripotentes para estudios del desarrollo embrionario y la diferenciación celular, herramientas para detección in vitro de nuevos medicamentos y evaluación de su eficacia y toxicidad, desarrollo de modelos in vitro de enfermedades humanas y uso en terapia celular. Las iPS, son células que muestran características fenotípicas y funcionales similares a las observadas en células madre embrionarias, sin los cuestionamientos éticos y legales de la manipulación de embriones. En articular, la generación de las células pluripotentes inducidas paciente-específicas ha permitido dilucidar los procesos fisiopatológicos de diversas enfermedades genéticas de etiología conocida y desconocida, así como plantean la posibilidad de realizar terapia celular autóloga y terapia génica basada en células para la regeneración tisular dependiendo de las necesidades individuales.
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A la Vicerrectoría de Investigaciones de la Universidad Militar Nueva Granada por la financiación del proyecto Med573Referencias bibliográficas
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