Papel de las adaptaciones epigenéticas en el riesgo de enfermedades cardiovasculares en la población latinoamericana

  • Patricio López-Jaramillo FOSCAL
  • Daniel Cohen London Metropolitan University
  • Carlos Velandia FOSCAL
  • Arístides Sotomayor-Rubio Universidad Autónoma de Bucaramanga
  • Katherine Rincón-Romero Universidad de Santander
  • José López-López Universidad Autónoma de Bucaramanga
  • Diego Gómez Arbeláez Universidad de Santander
Palabras clave: actividad física, epigenética, enfermedades cardiovasculares, diabetes mellitus, obesidad

Resumen

Las enfermedades cardio-metabólicas (obesidad, diabetes mellitus tipo 2, infarto agudo de miocardio y accidente cerebro-vascular) son al momento el problema de salud pública más relevante en Colombia. La rápida urbanización experimentada por el país en los últimos 50 años, así como los cambios en los hábitos nutricionales y en la actividad física asociada a la urbanización han determinado que en el proceso de adaptación biológica de la población colombiana a este rápido proceso medioambiental, se sobre expresen por vía epigenética, substancias pro inflamatorias y aquellas que llevan a resistencia a la insulina, mecanismo que confiere una mayor susceptibilidad para que nuestra población desarrolle las enfermedades cardio-metabólicas. Este proceso es especialmente grave en los niños escolares de nuestras ciudades. De frente a esta situación, en el presente artículo revisamos una serie de evidencias que nos llevan a proponer que el ejercicio, especialmente el de fuerza puede, vía epigenética, determinar un mayor desarrollo de masa muscular y la expresión de sustancias producidas en el músculo que tienen propiedades anti inflamatorias y que mejoran la sensibilidad a la insulina, por lo cual se contraponen al estado de resistencia a la insulina y a la inflamación de bajo grado, producto de la obesidad especialmente abdominal.

Biografía del autor/a

Patricio López-Jaramillo, FOSCAL
Dirección de Investigaciones, Desarrollo e Innovación Tecnológica, Fundación Oftalmológica de Santander-Clínica Carlos Ardila Lulle (FOSCAL). Dirección de Investigaciones, Facultad de Medicina, Universidad de Santander (UDES).
Daniel Cohen, London Metropolitan University
London Metropolitan University
Carlos Velandia, FOSCAL
Dirección de Investigaciones, Desarrollo e Innovación Tecnológica, Fundación Oftalmológica de Santander-Clínica Carlos Ardila Lulle (FOSCAL). Dirección de Investigaciones, Facultad de Medicina, Universidad de Santander (UDES).
Arístides Sotomayor-Rubio, Universidad Autónoma de Bucaramanga
Facultad de Medicina, Universidad Autónoma de Bucaramanga
Katherine Rincón-Romero, Universidad de Santander
Dirección de Investigaciones, Facultad de Medicina, Universidad de Santander
José López-López, Universidad Autónoma de Bucaramanga
Facultad de Medicina, Universidad Autónoma de Bucaramanga
Diego Gómez Arbeláez, Universidad de Santander
Dirección de Investigaciones, Facultad de Medicina, Universidad de Santander (UDES)

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Biografía del autor/a

Patricio López-Jaramillo, FOSCAL
Dirección de Investigaciones, Desarrollo e Innovación Tecnológica, Fundación Oftalmológica de Santander-Clínica Carlos Ardila Lulle (FOSCAL). Dirección de Investigaciones, Facultad de Medicina, Universidad de Santander (UDES).
Daniel Cohen, London Metropolitan University
London Metropolitan University
Carlos Velandia, FOSCAL
Dirección de Investigaciones, Desarrollo e Innovación Tecnológica, Fundación Oftalmológica de Santander-Clínica Carlos Ardila Lulle (FOSCAL). Dirección de Investigaciones, Facultad de Medicina, Universidad de Santander (UDES).
Arístides Sotomayor-Rubio, Universidad Autónoma de Bucaramanga
Facultad de Medicina, Universidad Autónoma de Bucaramanga
Katherine Rincón-Romero, Universidad de Santander
Dirección de Investigaciones, Facultad de Medicina, Universidad de Santander
José López-López, Universidad Autónoma de Bucaramanga
Facultad de Medicina, Universidad Autónoma de Bucaramanga
Diego Gómez Arbeláez, Universidad de Santander
Dirección de Investigaciones, Facultad de Medicina, Universidad de Santander (UDES)

Referencias bibliográficas

Murray CJ, Lopez AD. Global mortality, disability, and the contribution of risk factors: Global Burden of Disease Study. Lancet. 1997;349:1436-42.

Ford ES, Ajani UA, Croft J B et al. Explaining the decrease in U.S. deaths from coronary disease, 1980-2000. N Engl J Med. 2007;356:2388-98.

Brochu M, Tchernof A, Dionne IJ, et al. What are the physical characteristics associated with a normal metabolic profile despite a high level of obesity in postmenopausal women? J Clin Endocrinol Metab. 2001;86:1020-25.

Ferrannini E, Natali A, Bell P, Cavallo-Perin P, Lalic N, Mingrone G. Insulin resistance and hypersecretion in obesity. European Group for the Study of Insulin Resistance (EGIR). J Clin Invest. 1997;100:1166-73.

Karelis AD, Brochu M, Rabasa-Lhoret R. Can we identify metabolically healthy but obese individuals (MHO)? Diabetes Metab. 2004;30:569-72.

Ogden CL, Flegal KM, Carroll MD, Johnson CL. Prevalence and trends in overweight among US children and adolescents, 1999-2000. JAMA. 2002;288:1728-32.

Okosun I S, Liao Y, Rotimi CN, Prewitt TE, Cooper RS. Abdominal adiposity and clustering of multiple metabolic syndrome in White, Black and Hispanic americans. Ann Epidemiol. 2000;10:263-70.

Lanas F, Avezum A, Bautista LE, et al. Risk factors for acute myocardial infarction in Latin America: the INTERHEART Latin American study. Circulation. 2007;115:1067-74.

O’Donnell M J, Xavier D, Liu L et al. Risk factors for ischaemic and intracerebral haemorrhagic stroke in 22 countries (the INTERSTROKE study): A case-control study. Lancet. 2010;376:112-23.

Ford ES. C-reactive protein concentration and cardiovascular disease risk factors in children: findings from the National Health and Nutrition Examination Survey 1999-2000. Circulation. 2003;108:1053-58.

Baumann H, Gauldie J. Regulation of hepatic acute phase plasma protein genes by hepatocyte stimulating factors and other mediators of inflammation. Mol Biol Med. 1990;7:147-59.

Wellen KE, Hotamisligil GS. Obesity-induced inflammatory changes in adipose tissue. J Clin Invest. 2003;112:1785-1788.

Cook DG, Mendall MA, Whincup P H et al. C-reactive protein concentration in children: relationship to adiposity and other cardiovascular risk factors. Atherosclerosis. 2000;149:139-50.

López-Jaramillo P, Herrera E, García RG, Camacho PA, Castillo VR. Inter-relationships between body mass index, C-reactive protein and blood pressure in a Hispanic pediatric population. Am J Hypertens. 2008;21:527-32.

Aeberli I, Molinari L, Spinas G, Lehmann R, l’Allemand D, Zimmermann MB. Dietary intakes of fat and antioxidant vitamins are predictors of subclinical inflammation in overweight Swiss children. Am J Clin Nutr. 2006;84:748-55.

Weiss R, Dziura J, Burgert T S et al. Obesity and the metabolic syndrome in children and adolescents. N Engl J Med. 2004;350:2362-74.

López-Jaramillo P. Defining the research priorities to fight the burden of cardiovascular diseases in Latin America. J Hypertens. 2008;26:1886-89.

López-Jaramillo P, Silva SY, Rodriguez-Salamanca N, Duran A, Mosquera W, Castillo V. Are nutrition-induced epigenetic changes the link between socioeconomic pathology and cardiovascular diseases? Am J Ther. 2008;15:362-72.

García RG, Cifuentes AE, Caballero RS, Sanchez L, Lopez-Jaramillo P. A proposal for an appropriate central obesity diagnosis in Latin American population. Int J Cardiol. 2006;110:263-64.

García RG, Pérez M, Maas R, Schwedhelm E, Boger RH, Lopez-Jaramillo P. Plasma concentrations of asymmetric dimethylarginine (ADMA) in metabolic syndrome. Int J Cardiol. 2007;122:176-8.

García RG, Rincón MY, Arenas W D et al. Hyperinsulinemia is a predictor of new cardiovascular events in Colombian patients with a first myocardial infarction. Int J Cardiol. 2011;148:85-90.

López-Jaramillo P, Rueda-Clausen CF, Silva FA. The utility of different definitions of metabolic syndrome in Andean population. Int J Cardiol. 2007;116:421-2.

Pérez M, Casas J P, Cubillos-Garzon L A et al. Using waist circumference as a screening tool to identify Colombian subjects at cardiovascular risk. Eur J Cardiovasc Prev Rehabil. 2003;10:328-35.

Rueda-Clausen CF, Lahera V, Calderon J, et al. The presence of abdominal obesity is associated with changes in vascular function independently of other cardiovascular risk factors. Int J Cardiol. 139:32-41.

Rueda-Clausen CF, Lopez-Jaramillo P, Luengas C, del Pilar Oubina M, Cachofeiro V, Lahera V. Inflammation but not endothelial dysfunction is associated with the severity of coronary artery disease in dyslipidemic subjects. Mediators Inflamm. 2009;2009:ID 469169. 26. Gallou-Kabani C, Junien C. Nutritional epigenomics of metabolic syndrome: new perspective against the epidemic. Diabetes. 2005;54:1899-906.

Lopez-Jaramillo P. Cardiometabolic disease in Latin America: the role of fetal programming in response to maternal malnutrition. Rev Esp Cardiol. 2009;62:670-76

Argiles JM, Lopez-Soriano J, Almendro V, Busquets S, Lopez-Soriano FJ. Cross-talk between skeletal muscle and adipose tissue: a link with obesity? Med Res Rev. 2005;25:49-65.

Hiscock N, Chan MH, Bisucci T, Darby IA, Febbraio MA. Skeletal myocytes are a source of interleukin-6 mRNA expression and protein release during contraction: Evidence of fiber type specificity. Faseb J. 2004;18:992-4.

Nielsen AR, Mounier R, Plomgaard P, et al. Expression of interleukin-15 in human skeletal muscle: effect of exercise and muscle fibre type composition. J Physiol. 2007;584:305-12.

Walsh K. Adipokines, myokines and cardiovascular disease. Circ J. 2009;73:13-8.

Brandt C, Pedersen BK. The role of exercise-induced myokines in muscle homeostasis and the defense against chronic diseases. J Biomed Biotechnol. 2010;2010:ID 520258.

Nielsen A R, Hojman P, Erikstrup C et al. Association between interleukin-15 and obesity: interleukin-15 as a potential regulator of fat mass. J Clin Endocrinol Metab. 2008;93:4486-93.

Visser M, Pahor M, Taaffe D R et al. Relationship of interleukin-6 and tumor necrosis factor-alpha with muscle mass and muscle strength in elderly men and women: the Health ABC Study. J Gerontol A Biol Sci Med Sci. 2002;57:326-32.

Schaap LA, Pluijm SM, Deeg D J et al. Higher inflammatory marker levels in older persons: associations with 5-year change in muscle mass and muscle strength. J Gerontol A Biol Sci Med Sci. 2009;64:1183-89.

Ruiz JR, Sui X, Lobelo F et al. Association between muscular strength and mortality in men: prospective cohort study. BMJ. 2008;337:439.

Ruiz JR, Ortega F B, Warnberg J et al. Inflammatory proteins and muscle strength in adolescents: the Avena study. Arch Pediatr Adolesc Med. 2008;162:462-68.

Donges C E, Duffield R, Drinkwater EJ. Effects of resistance or aerobic exercise training on interleukin-6, C-reactive protein, and body composition. Med Sci Sports Exerc. 2010;42:304-13.

Ramos-Bermudez S, Alonso-Alzate G, Salazar D. Evaluación antropométrica y motriz condicional de niños y adolescentes. 1ª ed. Manizales, Colombia: Editorial Universidad de Caldas; 2007.

Cohen D, Voss C, taylor M, Delextrat A, Ogunleye A, Sandercock G. Ten-Year secular changes in muscular fitness in English children. Acta Paediatr. 2011;100:175-77.

Schlussel MM, dos Anjos LA, de Vasconcellos MT, Kac G. Reference values of handgrip dynamometry of healthy adults: a population-based study. Clin Nutr. 2008;27:601-7.

Chumlea WC, Guo SS, Kuczmarski R J et al. Body composition estimates from NHANES III bioelectrical impedance data. Int J Obes Relat Metab Disord. 2002;26:1596-609.

Shaibi GQ, Ball GD, Goran MI. Aerobic fitness among Caucasian, African-American, and Latino youth. Ethn Dis. Winter. 2006;16:120-5.

Hales CN, Barker DJ. The thrifty phenotype hypothesis. Br Med Bull. 2001;60:5-20.

Wells JC, Chomtho S, Fewtrell MS. Programming of body composition by early growth and nutrition. Proc Nutr Soc. 2007;66:423-34.

Sayer AA, Cooper C. Fetal programming of body composition and musculo skeletal development. Early Hum Dev. 2005;81:735-44.

Ozanne SE, Jensen CB, Tingey KJ, Storgaard H, Madsbad S, Vaag AA. Low birthweight is associated with specific changes in muscle insulin-signalling protein expression. Diabetologia. 2005;48:547-52.

Ozanne SE, Jensen CB, Tingey K J et al. Decreased protein levels of key insulin signaling molecules in adipose tissue from young men with a low birth weight: potential link to increased risk of diabetes? Diabetologia. 2006;49:2993-9.

Jensen CB, Martin-Gronert MS, Storgaard H, Madsbad S, Vaag A, Ozanne SE. Altered PI3-kinase/Akt signalling in skeletal muscle of young men with low birth weight. PLoS One. 2008;3:3738.

Jensen CB, Storgaard H, Madsbad S, Richter EA, Vaag AA. Altered skeletal muscle fiber composition and size precede whole-body insulin resistance in young men with low birth weight. J Clin Endocrinol Metab. 2007;92:1530-4.

Laaksonen DE, Lakka H M, Lynch J et al. Cardio respiratory fitness and vigorous leisure-time physical activity modify the association of small size at birth with the metabolic syndrome. Diabetes Care. 2003;26:2156-64.

Nazmi A, Victora CG. Socioeconomic and racial/ethnic differentials of C-reactive protein levels: a systematic review of populationbased studies. BMC Public Health. 2007;7:212.

Koutoubi S, Huffman FG. Body composition assessment and coronary heart disease risk factors among college students of three ethnic groups. J Natl Med Assoc. 2005;97:784-91.

Brooks N, Layne JE, Gordon PL, Roubenoff R, Nelson ME, Castaneda-Sceppa C. Strength training improves muscle quality and insulin sensitivity in Hispanic older adults with type 2 diabetes. Int J Med Sci. 2007;4:19-27.

Ramírez-Vélez R, Aguilar de Plata AC, Escudero MM, Echeverry I, Ortega JG, Salazar B, Rey JJ, Hormiga C, López-Jaramillo P. Influence of regular aerobic exercise on endothelium-dependent vasodilation and cardio respiratory fitness in pregnant women. J Obstet Gynecol Res. 2011;37:1601

López-Jaramillo P, Oubiña P, Valero S, Ballesteros S, Lahera V, Rodriguez Y, Garcia R, Gomez-Arbelaez D. Aged Garlic Extract increases adiponectin levels in subjects with metabolic syndrome. J. Diab 2011;3:51.

Shaibi GQ, Cruz ML, Ball G D et al. Effects of resistance training on insulin sensitivity in overweight Latino adolescent males. Med Sci Sports Exerc. 2006;38:1208-15.

Sherriff A, Wright CM, Reilly JJ, McColl J, Ness A, Emmett P. Age- and sex-standardised lean and fat indices derived from bioelectrical impedance analysis for ages 7-11 years: functional associations with cardio-respiratory fitness and grip strength. Br J Nutr. 2009;101:1753-1760.

Ortega FB, Artero EG, Ruiz J R et al. Reliability of health-related physical fitness tests in European adolescents. The HELENA Study. Int J Obes. 2008;32:49-57.

Milliken LA, Faigenbaum AD, Loud RL, Westcott WL. Correlates of upper and lower body muscular strength in children. J Strength Cond Res. 2008;22:1339-46.

Rankinen T, Zuberi A, Chagnon YC, Weisnagel SJ, Argyropoulos G, Walts B, Pérusse L, Bouchard C. The human obesity gene map: the 2005 update. Obesity. 2006;14:529-644.

Thorleifsson G, Walters GB, Gudbjartsson DF et al. Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity. Nat Genet. 2009;41:18-24.

Walley AJ, Asher JE, Froguel P. The genetic contribution to nonsyndromic human obesity. Nat Rev Genet. 2009;10:431-42.

Bogardus C. Missing heritability and GWAS utility. Obesity. 2009;17:209-10.

Walters RG, Jacquemont S, Valsesia A et al. A new highly penetrant form of obesity due to deletions on chromosome 16p11.2. Nature. 2011;463:671-75.

Campion J, Milagro FI, Martinez JA. Individuality and epigenetics in obesity. Obes Rev. 2009;10:383-92.

Heerwagen MJ, Miller MR, Barbour LA, Friedman JE. Maternal Obesity and Fetal Metabolic Programming: A Fertile Epigenetic Soil. Am J Physiol Regul Integr Comp Physiol. 2010;299:711-22.J

Cómo citar
López-Jaramillo, P., Cohen, D., Velandia, C., Sotomayor-Rubio, A., Rincón-Romero, K., López-López, J., & Gómez Arbeláez, D. (2011). Papel de las adaptaciones epigenéticas en el riesgo de enfermedades cardiovasculares en la población latinoamericana. Revista Med, 19(1), 93–99. https://doi.org/10.18359/rmed.1220
Publicado
2011-06-30
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