El gran papel de Klotho
Resumen
Klotho es una proteína transmembrana de un solo paso que consta de 1012 aminoácidos y se expresa fuerte y débilmente en células epiteliales renales tubulares distales y proximales, respectivamente. Hay cuatro grupos de proteínas Klotho. El gen α Klotho se expresa abundantemente en riñones, glándulas paratiroides, plexo coroideo, y también en la corteza cerebral, la médula espinal, cerebelo, hipotálamo, hipófisis, glándulas paratiroides, ovario, testículos, células epiteliales del seno, placenta, páncreas, oído interno, vascular células del músculo liso o intestino. KLOTHO exhibe múltiples funciones, además de la excreción de fosfato, incluida la mejora del estrés oxidativo y la inhibición de vías de señalización del factor de crecimiento de insulina, Wnt / β-catenina, transformación del factor de crecimiento -β1, y el objetivo mecanicista de la señalización de rapamicina, obteniendo un importante papel dentro de un sin número de eventos patológicos como el que generó la reciente pandemia. Tanto nuevos trabajos como anteriores en humanos y los ratones proporcionan una fuerte justificación para examinar más a fondo el papel del klotho en la salud y el envejecimiento.
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