Papel de las adaptaciones epigenéticas en el riesgo de enfermedades cardiovasculares en la población latinoamericana

  • Patricio López-Jaramillo FOSCAL
  • Daniel Cohen London Metropolitan University
  • Carlos Velandia FOSCAL
  • Arístides Sotomayor-Rubio Universidad Autónoma de Bucaramanga
  • Katherine Rincón-Romero Universidad de Santander
  • José López-López Universidad Autónoma de Bucaramanga
  • Diego Gómez Arbeláez Universidad de Santander
Palabras clave: actividad física, epigenética, enfermedades cardiovasculares, diabetes mellitus, obesidad

Resumen

Las enfermedades cardio-metabólicas (obesidad, diabetes mellitus tipo 2, infarto agudo de miocardio y accidente cerebro-vascular) son al momento el problema de salud pública más relevante en Colombia. La rápida urbanización experimentada por el país en los últimos 50 años, así como los cambios en los hábitos nutricionales y en la actividad física asociada a la urbanización han determinado que en el proceso de adaptación biológica de la población colombiana a este rápido proceso medioambiental, se sobre expresen por vía epigenética, substancias pro inflamatorias y aquellas que llevan a resistencia a la insulina, mecanismo que confiere una mayor susceptibilidad para que nuestra población desarrolle las enfermedades cardio-metabólicas. Este proceso es especialmente grave en los niños escolares de nuestras ciudades. De frente a esta situación, en el presente artículo revisamos una serie de evidencias que nos llevan a proponer que el ejercicio, especialmente el de fuerza puede, vía epigenética, determinar un mayor desarrollo de masa muscular y la expresión de sustancias producidas en el músculo que tienen propiedades anti inflamatorias y que mejoran la sensibilidad a la insulina, por lo cual se contraponen al estado de resistencia a la insulina y a la inflamación de bajo grado, producto de la obesidad especialmente abdominal.

Biografía del autor/a

Patricio López-Jaramillo, FOSCAL
Dirección de Investigaciones, Desarrollo e Innovación Tecnológica, Fundación Oftalmológica de Santander-Clínica Carlos Ardila Lulle (FOSCAL). Dirección de Investigaciones, Facultad de Medicina, Universidad de Santander (UDES).
Daniel Cohen, London Metropolitan University
London Metropolitan University
Carlos Velandia, FOSCAL
Dirección de Investigaciones, Desarrollo e Innovación Tecnológica, Fundación Oftalmológica de Santander-Clínica Carlos Ardila Lulle (FOSCAL). Dirección de Investigaciones, Facultad de Medicina, Universidad de Santander (UDES).
Arístides Sotomayor-Rubio, Universidad Autónoma de Bucaramanga
Facultad de Medicina, Universidad Autónoma de Bucaramanga
Katherine Rincón-Romero, Universidad de Santander
Dirección de Investigaciones, Facultad de Medicina, Universidad de Santander
José López-López, Universidad Autónoma de Bucaramanga
Facultad de Medicina, Universidad Autónoma de Bucaramanga
Diego Gómez Arbeláez, Universidad de Santander
Dirección de Investigaciones, Facultad de Medicina, Universidad de Santander (UDES)

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Biografía del autor/a

Patricio López-Jaramillo, FOSCAL
Dirección de Investigaciones, Desarrollo e Innovación Tecnológica, Fundación Oftalmológica de Santander-Clínica Carlos Ardila Lulle (FOSCAL). Dirección de Investigaciones, Facultad de Medicina, Universidad de Santander (UDES).
Daniel Cohen, London Metropolitan University
London Metropolitan University
Carlos Velandia, FOSCAL
Dirección de Investigaciones, Desarrollo e Innovación Tecnológica, Fundación Oftalmológica de Santander-Clínica Carlos Ardila Lulle (FOSCAL). Dirección de Investigaciones, Facultad de Medicina, Universidad de Santander (UDES).
Arístides Sotomayor-Rubio, Universidad Autónoma de Bucaramanga
Facultad de Medicina, Universidad Autónoma de Bucaramanga
Katherine Rincón-Romero, Universidad de Santander
Dirección de Investigaciones, Facultad de Medicina, Universidad de Santander
José López-López, Universidad Autónoma de Bucaramanga
Facultad de Medicina, Universidad Autónoma de Bucaramanga
Diego Gómez Arbeláez, Universidad de Santander
Dirección de Investigaciones, Facultad de Medicina, Universidad de Santander (UDES)

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Cómo citar
López-Jaramillo, P., Cohen, D., Velandia, C., Sotomayor-Rubio, A., Rincón-Romero, K., López-López, J., & Gómez Arbeláez, D. (2011). Papel de las adaptaciones epigenéticas en el riesgo de enfermedades cardiovasculares en la población latinoamericana. Revista Med, 19(1), 93-99. https://doi.org/10.18359/rmed.1220
Publicado
2011-06-30
Sección
Artículos