@article{Bernal_Cuca_Fadini_2015, title={A Facile Approach toward 8-O-4’-Neolignans: Synthesis of Threo-7’,8’-Dihydromachilin D through Jacobsen Epoxidation}, volume={11}, url={https://revistas.unimilitar.edu.co/index.php/rfcb/article/view/385}, DOI={10.18359/rfcb.385}, abstractNote={<p class="Default"> Neolignans are natural phenylpropanoid dimers with C-O-C linkages. Currently, neolignans remain as im­portant synthetic targets due to their reported biological potential against parasites and fungal infections. Thereof, a new approach for the synthesis of the 8-<em>O</em>-4'-neolignan 7',8'-dihydromachilin D based on Jacobsen epoxidation as key step is described here. This stereoselective synthesis proceeded in only 4 steps in 3.9% overall yield. Jacobsen epoxidation was firstly optimized regarding to yield and enantioselectivity employing <em>trans</em>-stilbene as model substrate.</p>}, number={1}, journal={Revista Facultad de Ciencias Básicas}, author={Bernal, Freddy A. and Cuca, Luis E. and Fadini, Luca}, year={2015}, month={ene.}, pages={114–129} }